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obst-E obstructor-E [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33806, updated on 4-Jan-2025

Summary

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Official Symbol
obst-Eprovided by FlyBase
Official Full Name
obstructor-Eprovided by FlyBase
Primary source
FLYBASE:FBgn0031737
Locus tag
Dmel_CG11142
See related
AllianceGenome:FB:FBgn0031737
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11142; Dmel\CG11142; Obst-E
Summary
Enables chitin binding activity. A structural constituent of chitin-based larval cuticle and structural constituent of pupal chitin-based cuticle. Involved in chitin-based cuticle development. Located in chitin-based extracellular matrix. Is expressed in adult brain cell body rind and cuticle. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See obst-E in Genome Data Viewer
Location:
25F4-25F4; 2-17 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5762553..5766142, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5762553..5766142, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR31912 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mechanical Control of Whole Body Shape by a Single Cuticular Protein Obstructor-E in Drosophila melanogaster. Tajiri R, et al. PLoS Genet, 2017 Jan. PMID 28076349, Free PMC Article
  2. Notch signaling generates the "cut here line" on the cuticle of the puparium in Drosophila melanogaster. Tajiri R, et al. iScience, 2023 Aug 18. PMID 37529108, Free PMC Article
  3. Tweedle proteins form extracellular two-dimensional structures defining body and cell shape in Drosophila melanogaster. Zuber R, et al. Open Biol, 2020 Dec. PMID 33292106, Free PMC Article
  4. Identification of the novel evolutionary conserved obstructor multigene family in invertebrates. Behr M, et al. FEBS Lett, 2005 Dec 19. PMID 16325182
  5. Reduction in maternal Polycomb levels contributes to transgenerational inheritance of a response to toxic stress in flies. Stern S, et al. J Physiol, 2014 Jun 1. PMID 24535443, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Obst-E regulates the arrangement of chitin and directs the formation of supracellular ridges on the larval cuticle.
    Title: Mechanical Control of Whole Body Shape by a Single Cuticular Protein Obstructor-E in Drosophila melanogaster.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chitin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chitin binding IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of chitin-based larval cuticle IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of pupal chitin-based cuticle IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in chitin-based cuticle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chitin-based extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
obstructor-E
Names
CG11142-PA
CG11142-PB
obst-E-PA
obst-E-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    5762553..5766142 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_164659.3 → NP_723116.1  obstructor-E, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723116.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IGU3, Q8T0V6, Q9VMM6
    Related
    FBpp0078795
    Conserved Domains (2) summary
    smart00494
    Location:23 → 65
    ChtBD2; Chitin-binding domain type 2
    pfam01607
    Location:180 → 225
    CBM_14; Chitin binding Peritrophin-A domain

  2. NM_135113.3 → NP_608957.1  obstructor-E, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608957.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VMM6
    Related
    FBpp0078794
    Conserved Domains (1) summary
    pfam01607
    Location:103 → 147
    CBM_14; Chitin binding Peritrophin-A domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VMM6.2 Q9VMM6

Gene LinkOut

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