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FLT4 fms related receptor tyrosine kinase 4 [ Bos taurus (domestic cattle) ]

Gene ID: 338031, updated on 1-Jan-2025

Summary

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Official Symbol
FLT4provided by VGNC
Official Full Name
fms related receptor tyrosine kinase 4provided by VGNC
Primary source
VGNC:VGNC:29044
See related
BGD:BT10135; Ensembl:ENSBTAG00000001462
Gene type
protein coding
RefSeq status
MODEL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See FLT4 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (496623..537882)

Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100125913 Neighboring gene 5S ribosomal RNA Neighboring gene CCR4-NOT transcription complex subunit 6 Neighboring gene transfer RNA histidin (anticodon AUG) Neighboring gene glutamine-fructose-6-phosphate transaminase 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. Vascular endothelial growth factor (VEGF)-C synergizes with basic fibroblast growth factor and VEGF in the induction of angiogenesis in vitro and alters endothelial cell extracellular proteolytic activity. Pepper MS, et al. J Cell Physiol, 1998 Dec. PMID 9808152
  2. The urokinase plasminogen activator system components are regulated by vascular endothelial growth factor D in bovine oviduct. García DC, et al. Zygote, 2018 Jun. PMID 29880066
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FLT4 (VEGFR3) expression in the oviducts.
    Title: The urokinase plasminogen activator system components are regulated by vascular endothelial growth factor D in bovine oviduct.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables growth factor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in vascular endothelial growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
vascular endothelial growth factor receptor 3
Names
fms related tyrosine kinase 4
XP_010804757.2
XP_024850494.1
XP_024850495.1
XP_059744470.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    496623..537882
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_010806455.3 → XP_010804757.2  vascular endothelial growth factor receptor 3 isoform X1

    UniProtKB/TrEMBL
    A0AAA9SVL9, F1MHP5
    Related
    ENSBTAP00000039997.5, ENSBTAT00000040219.6
    Conserved Domains (6) summary
    cd05862
    Location:248 → 332
    Ig_VEGFR; Immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R)
    smart00408
    Location:697 → 759
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:575 → 661
    IG; Immunoglobulin
    pfam13895
    Location:140 → 227
    Ig_2; Immunoglobulin domain
    cl11960
    Location:355 → 421
    Ig; Immunoglobulin domain
    cl21453
    Location:841 → 1180
    PKc_like; Protein Kinases, catalytic domain

  2. XM_024994727.2 → XP_024850495.1  vascular endothelial growth factor receptor 3 isoform X3

    UniProtKB/TrEMBL
    A0AAA9SVL9
    Conserved Domains (6) summary
    cd05862
    Location:248 → 332
    Ig_VEGFR; Immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R)
    smart00408
    Location:697 → 759
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:575 → 661
    IG; Immunoglobulin
    pfam13895
    Location:140 → 227
    Ig_2; Immunoglobulin domain
    cl11960
    Location:355 → 421
    Ig; Immunoglobulin domain
    cl21453
    Location:841 → 1180
    PKc_like; Protein Kinases, catalytic domain

  3. XM_024994726.2 → XP_024850494.1  vascular endothelial growth factor receptor 3 isoform X2

    UniProtKB/TrEMBL
    A0AAA9SVL9
    Conserved Domains (5) summary
    cd05862
    Location:248 → 332
    Ig_VEGFR; Immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R)
    smart00408
    Location:696 → 758
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:574 → 660
    IG; Immunoglobulin
    cl11960
    Location:355 → 421
    Ig; Immunoglobulin domain
    cl21453
    Location:840 → 1179
    PKc_like; Protein Kinases, catalytic domain

  4. XM_059888487.1 → XP_059744470.1  vascular endothelial growth factor receptor 3 isoform X4

    UniProtKB/TrEMBL
    A0AAA9SVL9
    Related
    ENSBTAP00000087232.1, ENSBTAT00000131808.1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001191344.1: Suppressed sequence

    Description
    NM_001191344.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
Nucleotide Protein Strain
Heading Accession and Version

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