Hsp60C Heat shock protein 60C [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Hsp60Cprovided by FlyBase
Official Full Name: Heat shock protein 60Cprovided by FlyBase
Primary source: FLYBASE:FBgn0031728
Locus tag: Dmel_CG7235
See related: AllianceGenome:FB:FBgn0031728
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: A4V087_DROME; bs36d10.y1; CG7235; Dm25E; Dmel\CG7235; Hsp60; hsp60c; hsp60C; HSP60C; Hsp64; Q9VMN5
Summary: Predicted to enable ATP hydrolysis activity and protein-folding chaperone binding activity. Involved in oogenesis; open tracheal system development; and spermatogenesis. Predicted to be active in mitochondrial inner membrane and mitochondrial matrix. Is expressed in several structures, including adult head; adult visceral muscle cell; ejaculatory duct; germline cell; and gland. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autistic disorder; glucose intolerance; hereditary spastic paraplegia (multiple); and hypomyelinating leukodystrophy 4. Orthologous to human HSPD1 (heat shock protein family D (Hsp60) member 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 25F2-25F2; 2-17 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (5662849..5670838)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (5662849..5670838)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results provide the first evidence for an essential role of Hsp60C in Drosophila oogenesis, especially in organization and maintenance of cytoskeletal and cell adhesion components.
Title: Hsp60C is required in follicle as well as germline cells during oogenesis in Drosophila melanogaster.
we characterized the Hsp60C gene (at 25F region), which shows high sequence homology with the other three Hsp60 genes of D. melanogaster.Hsp60C may also be involved in cation transport across the developing tracheal epithelial cells
Title: The Hsp60C gene in the 25F cytogenetic region in Drosophila melanogaster is essential for tracheal development and fertility.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	ISS Inferred from Sequence or Structural Similarity more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables protein-folding chaperone binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in apoptotic mitochondrial changes	IBA Inferred from Biological aspect of Ancestor more info
involved_in female germline ring canal formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in follicle cell of egg chamber development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial unfolded protein response	IBA Inferred from Biological aspect of Ancestor more info
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into mitochondrial intermembrane space	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein refolding	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: heat shock protein 60C

Names: 60 kDa heat shock protein homolog 2 mitochondrial; CG7235-PA; CG7235-PB; CG7235-PC; Hsp60C-PA; Hsp60C-PB; Hsp60C-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

5662849..5670838

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_164654.2 → NP_723104.2 heat shock protein 60C, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723104.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V087, Q8IHD0, Q8MZB0, Q9VMN5

Related

FBpp0078742

Conserved Domains (2) summary

PTZ00114
Location:23 → 553

PTZ00114; Heat shock protein 60; Provisional

cd03344
Location:28 → 548

GroEL; GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found ...
NM_135104.5 → NP_608948.2 heat shock protein 60C, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_608948.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V087, Q8IHD0, Q8MZB0, Q9VMN5

Related

FBpp0078743

Conserved Domains (2) summary

PTZ00114
Location:23 → 553

PTZ00114; Heat shock protein 60; Provisional

cd03344
Location:28 → 548

GroEL; GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found ...
NM_164655.3 → NP_723105.2 heat shock protein 60C, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723105.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V087, Q8IHD0, Q8MZB0, Q9VMN5

Related

FBpp0078744

Conserved Domains (2) summary

PTZ00114
Location:23 → 553

PTZ00114; Heat shock protein 60; Provisional

cd03344
Location:28 → 548

GroEL; GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found ...