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tomb tombola [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33779, updated on 4-Jan-2025

Summary

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Official Symbol
tombprovided by FlyBase
Official Full Name
tombolaprovided by FlyBase
Primary source
FLYBASE:FBgn0031715
Locus tag
Dmel_CG14016
See related
AllianceGenome:FB:FBgn0031715
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14016; Dmel\CG14016; Tomb
Summary
Involved in positive regulation of transcription by RNA polymerase II and spermatogenesis. Acts upstream of with a positive effect on male meiosis I. Located in chromatin. Part of RNA polymerase II transcription regulator complex. Is active in nucleus. Is expressed in primary spermatocyte and testis. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See tomb in Genome Data Viewer
Location:
25E5-25E5; 2-17 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5535861..5536758, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5535861..5536758, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Chromosome associated protein D3 Neighboring gene Cytochrome c oxidase copper chaperone COX11 Neighboring gene uncharacterized protein Neighboring gene Coenzyme Q6 Neighboring gene uncharacterized protein Neighboring gene Helicase at 25E

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. De novo ORFs in Drosophila are important to organismal fitness and evolved rapidly from previously non-coding sequences. Reinhardt JA, et al. PLoS Genet, 2013. PMID 24146629, Free PMC Article
  2. FlyTED: the Drosophila Testis Gene Expression Database. Zhao J, et al. Nucleic Acids Res, 2010 Jan. PMID 19934263, Free PMC Article
  3. Evolution of chromatin-remodeling complexes: comparative genomics reveals the ancient origin of "novel" compensasome genes. Marín I. J Mol Evol, 2003 May. PMID 12698291
  4. A dual role of lola in Drosophila ovary development: regulating stem cell niche establishment and repressing apoptosis. Zhao T, et al. Cell Death Dis, 2022 Sep 2. PMID 36056003, Free PMC Article
  5. Determination of gene expression patterns using in situ hybridization to Drosophila testes. Morris CA, et al. Nat Protoc, 2009. PMID 20010932

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. tomb and aly might be components of a complex paralogous to the Drosophila dREAM/Myb-MuvB and C. elegans DRM transcriptional regulatory complexes.
    Title: Tombola, a tesmin/TSO1-family protein, regulates transcriptional activation in the Drosophila male germline and physically interacts with always early.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_positive_effect male meiosis I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tombola
Names
CG14016-PA
tomb-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    5535861..5536758 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135092.2 → NP_608936.1  tombola [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608936.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D4G7C3, Q9VMQ3
    Related
    FBpp0078758
    Conserved Domains (1) summary
    pfam03638
    Location:28 → 62
    TCR; Tesmin/TSO1-like CXC domain, cysteine-rich domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VMQ3 Q9VMQ3

Gene LinkOut

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