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Cyp4ac2 Cytochrome P450 4ac2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33755, updated on 4-Jan-2025

Summary

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Official Symbol
Cyp4ac2provided by FlyBase
Official Full Name
Cytochrome P450 4ac2provided by FlyBase
Primary source
FLYBASE:FBgn0031694
Locus tag
Dmel_CG17970
See related
AllianceGenome:FB:FBgn0031694
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
4ac2; CG17970; CYP4ac2; CYP4AC2; Dmel\CG17970
Summary
Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in adult head. Human ortholog(s) of this gene implicated in Bietti crystalline corneoretinal dystrophy. Orthologous to human CYP4V2 (cytochrome P450 family 4 subfamily V member 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Cyp4ac2 in Genome Data Viewer
Location:
25D2-25D2; 2-16 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5266392..5268455)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5266392..5268455)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene thickveins Neighboring gene long non-coding RNA:CR44744 Neighboring gene Cytochrome P450 4ac1 Neighboring gene Cytochrome P450 4ac3 Neighboring gene Ninein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genes and pathways affected by CAG-repeat RNA-based toxicity in Drosophila. Shieh SY, et al. Hum Mol Genet, 2011 Dec 15. PMID 21933837, Free PMC Article
  2. Cytochrome P450-dependent metabolism of caffeine in Drosophila melanogaster. Coelho A, et al. PLoS One, 2015. PMID 25671424, Free PMC Article
  3. Loss of Drosophila Clueless differentially affects the mitochondrial proteome compared to loss of Sod2 and Pink1. Sen A, et al. Front Physiol, 2022. PMID 36388112, Free PMC Article
  4. The molecular evolution of cytochrome P450 genes within and between drosophila species. Good RT, et al. Genome Biol Evol, 2014 Apr 20. PMID 24751979, Free PMC Article
  5. Characterization of Drosophila melanogaster cytochrome P450 genes. Chung H, et al. Proc Natl Acad Sci U S A, 2009 Apr 7. PMID 19289821, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytochrome P450 4ac2
Names
CG17970-PB
Cyp4ac2-PB
cytochrome P450
NP_608917.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    5266392..5268455
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135073.3 → NP_608917.3  cytochrome P450 4ac2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608917.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q4V4C1, Q9VMS8
    Conserved Domains (1) summary
    pfam00067
    Location:57 → 505
    p450; Cytochrome P450
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VMS8.4 Q9VMS8

Gene LinkOut

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