Fnta Farnesyl transferase alpha subunit [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Fntaprovided by FlyBase
Official Full Name: Farnesyl transferase alpha subunitprovided by FlyBase
Primary source: FLYBASE:FBgn0031633
Locus tag: Dmel_CG2976
See related: AllianceGenome:FB:FBgn0031633
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG2976; Dmel\CG2976; FNTA
Summary: Predicted to enable protein prenyltransferase activity. Predicted to contribute to CAAX-protein geranylgeranyltransferase activity and protein farnesyltransferase activity. Involved in positive regulation of Ras protein signal transduction. Predicted to be part of CAAX-protein geranylgeranyltransferase complex and protein farnesyltransferase complex. Predicted to be active in cytoplasm. Orthologous to human FNTA (farnesyltransferase, CAAX box, subunit alpha). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (4829214..4830693, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (4829214..4830693, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
contributes_to CAAX-protein geranylgeranyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to protein farnesyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein prenyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in peptide pheromone maturation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Ras protein signal transduction	HGI more info	PubMed
involved_in protein prenylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of CAAX-protein geranylgeranyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of protein farnesyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info

Names: CG2976-PA; CG2976-PB; Fnta-PA; Fnta-PB; farnesyl transferase alpha; farnesyl transferase alpha ortholog

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