tfg trafficking from ER to golgi regulator [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tfgprovided by ZNC
Official Full Name: trafficking from ER to golgi regulatorprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-8410
See related: Ensembl:ENSDARG00000003641 AllianceGenome:ZFIN:ZDB-GENE-030131-8410
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:55342; zgc:77230; wu:fb11c10
Summary: Predicted to enable identical protein binding activity. Acts upstream of or within regulation of neuron projection development and swimming behavior. Predicted to be active in endoplasmic reticulum exit site. Is expressed in brain; eye; notochord; pectoral fin; and spinal cord. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 57. Orthologous to human TFG (trafficking from ER to golgi regulator). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (30112423..30128760)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (30301677..30318014)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb11c10.x1 (e-PCR)
- UniSTS:190034

fb11c10.x1 (e-PCR)
- UniSTS:190035

z99206 (e-PCR), detects polymorphism
- UniSTS:238942

fe14g03.x1 (e-PCR)
- UniSTS:196205

AI384870 (e-PCR)
- UniSTS:206710

STS73.C3 (e-PCR)
- UniSTS:205700

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within COPII vesicle coating	IEA Inferred from Electronic Annotation more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within endoplasmic reticulum to Golgi vesicle-mediated transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within swimming behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum exit site	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein TFG

Names: trk-fused

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001328573.1 → NP_001315502.1 protein TFG

Status: VALIDATED

Source sequence(s)

BC065630, BX322575

UniProtKB/TrEMBL

A0A8M1PGB0, Q6P0G5

Related

ENSDARP00000099038.1, ENSDART00000112398.2

Conserved Domains (1) summary

cd06401
Location:11 → 91

PB1_TFG; The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in ...
NM_200015.2 → NP_956309.2 protein TFG

Status: VALIDATED

Source sequence(s)

BC065630, BX322575

UniProtKB/TrEMBL

A0A8M1PGB0, Q6P0G5

Related

ENSDARP00000009794.7, ENSDART00000013591.9

Conserved Domains (1) summary

cd06401
Location:11 → 91

PB1_TFG; The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in ...