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Tps1 Trehalose-6-phosphate synthase 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33642, updated on 9-Dec-2024

Summary

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Official Symbol
Tps1provided by FlyBase
Official Full Name
Trehalose-6-phosphate synthase 1provided by FlyBase
Primary source
FLYBASE:FBgn0027560
Locus tag
Dmel_CG4104
See related
AllianceGenome:FB:FBgn0027560
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
19920676; BcDNA:GH08860; CG4104; CG4104 PA; Dmel\CG4104; DmTPS1; dtps1; dTps1; jf5; l(2)24Ea; l(2)jf4; l(2)jf5; l(2)k08903; tps; TPS; tps1; TreS
Summary
Enables alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity and trehalose-phosphatase activity. Involved in trehalose biosynthetic process. Predicted to be located in cytoplasm. Is expressed in adult head; adult heart; spermatozoon; and yolk nucleus. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Tps1 in Genome Data Viewer
Location:
24E4-24E5; 2-12 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (4388327..4392778)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (4388327..4392778)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Vacuolar protein sorting 53 Neighboring gene Partner of Sld Five 2 Neighboring gene uncharacterized protein Neighboring gene lethal (2) k05819 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Discovering regulators of the Drosophila cardiac hypoxia response using automated phenotyping technology. Feala JD, et al. Ann N Y Acad Sci, 2008 Mar. PMID 18375589
  2. Downregulation of dTps1 in Drosophila melanogaster larvae confirms involvement of trehalose in redox regulation following desiccation. Thorat L, et al. Cell Stress Chaperones, 2016 Mar. PMID 26577464, Free PMC Article
  3. Expression of Drosophila trehalose-phosphate synthase in HEK-293 cells increases hypoxia tolerance. Chen Q, et al. J Biol Chem, 2003 Dec 5. PMID 13129920
  4. Trehalose-6-phosphate promotes fermentation and glucose repression in Saccharomyces cerevisiae. Vicente RL, et al. Microb Cell, 2018 Oct 1. PMID 30386789, Free PMC Article
  5. Eleven ancestral gene families lost in mammals and vertebrates while otherwise universally conserved in animals. Danchin EG, et al. BMC Evol Biol, 2006 Jan 18. PMID 16420703, Free PMC Article

See all (80) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. both Tps1 and Treh mutant larvae exhibit a high lethality after desiccation stress. These results demonstrate that the regulation of trehalose metabolism is essential for normal development, body water homeostasis, and desiccation tolerance in Drosophila.
    Title: Molecular characterization of Tps1 and Treh genes in Drosophila and their role in body water homeostasis.
  2. Insect trehalose synthesis is governed by the enzyme trehalose 6-phosphate synthase 1. Downregulation of Tps1 in Drosophila melanogaster larvae confirms involvement of trehalose in redox regulation following desiccation.
    Title: Downregulation of dTps1 in Drosophila melanogaster larvae confirms involvement of trehalose in redox regulation following desiccation.
  3. These diet-dependent phenotypes of Tps1 mutants demonstrate the critical role of trehalose during development in Drosophila and reveal how animals adapt to changes in nutrient availability.
    Title: Flies without trehalose.
  4. role in increasing hypoxia tolerance in human cells
    Title: Expression of Drosophila trehalose-phosphate synthase in HEK-293 cells increases hypoxia tolerance.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables trehalose-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables trehalose-phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in trehalose biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in trehalose biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in trehalose biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in trehalose metabolism in response to stress IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
Trehalose-6-phosphate synthase 1
Names
CG4104-PA
Tps1-PA
Trehalos-6-phosphate synthase
Trehalose-6-phosphate phosphatase
lethal(2)24Ea
trehalose synthase
trehalose-6-phosphate synthase
trehalose-phosphate synthase
NP_608827.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    4388327..4392778
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_134983.3 → NP_608827.1  Trehalose-6-phosphate synthase 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608827.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9Y119
    Related
    FBpp0077121
    Conserved Domains (3) summary
    cd03788
    Location:19 → 495
    GT1_TPS; Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a ...
    PRK14501
    Location:20 → 766
    PRK14501; putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional
    cl21460
    Location:530 → 770
    HAD_like; Haloacid Dehalogenase-like Hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y119 Q9Y119

Gene LinkOut

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