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Vps53 Vacuolar protein sorting 53 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33640, updated on 4-Jan-2025

Summary

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Official Symbol
Vps53provided by FlyBase
Official Full Name
Vacuolar protein sorting 53provided by FlyBase
Primary source
FLYBASE:FBgn0031598
Locus tag
Dmel_CG3338
See related
AllianceGenome:FB:FBgn0031598
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3338; Dmel\CG3338
Summary
Predicted to be involved in endocytic recycling and retrograde transport, endosome to Golgi. Predicted to be located in Golgi apparatus. Predicted to be part of GARP complex. Is expressed in adult head. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2E. Orthologous to human VPS53 (VPS53 subunit of GARP complex). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Vps53 in Genome Data Viewer
Location:
24E4-24E4; 2-12 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (4382925..4386062, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (4382925..4386062, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45363 Neighboring gene TNF-receptor-associated factor 4 Neighboring gene uncharacterized protein Neighboring gene Partner of Sld Five 2 Neighboring gene Trehalose-6-phosphate synthase 1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The GARP complex prevents sterol accumulation at the trans-Golgi network during dendrite remodeling. O'Brien CE, et al. J Cell Biol, 2023 Jan 2. PMID 36239632, Free PMC Article
  2. Developmental program-independent secretory granule degradation in larval salivary gland cells of Drosophila. Csizmadia T, et al. Traffic, 2022 Dec. PMID 36353974, Free PMC Article
  3. The small G protein Arl5 contributes to endosome-to-Golgi traffic by aiding the recruitment of the GARP complex to the Golgi. Rosa-Ferreira C, et al. Biol Open, 2015 Mar 20. PMID 25795912, Free PMC Article
  4. Model system identification of novel congenital heart disease gene candidates: focus on RPL13. Schroeder AM, et al. Hum Mol Genet, 2019 Dec 1. PMID 31625562, Free PMC Article
  5. The vacuolar protein sorting genes in insects: A comparative genome view. Li Z, et al. Insect Biochem Mol Biol, 2015 Jul. PMID 25486452

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in endocytic recycling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde transport, endosome to Golgi IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of GARP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of GARP complex IEA
Inferred from Electronic Annotation
more info
  
part_of GARP complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
vacuolar protein sorting 53
Names
CG3338-PA
Vps53-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    4382925..4386062 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_134981.3 → NP_608825.2  vacuolar protein sorting 53 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608825.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VQY8
    Related
    FBpp0077151
    Conserved Domains (1) summary
    pfam04100
    Location:42 → 434
    Vps53_N; Vps53-like, N-terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95TS1 Q95TS1
Q9VQY8 Q9VQY8

Gene LinkOut

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