Traf4 TNF-receptor-associated factor 4 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Traf4provided by FlyBase
Official Full Name: TNF-receptor-associated factor 4provided by FlyBase
Primary source: FLYBASE:FBgn0026319
Locus tag: Dmel_CG3048
See related: AllianceGenome:FB:FBgn0026319
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3048; Dmel\CG3048; dTRAF; DTRAF; dtraf1; dTraf1; dTRAF1; DTRAF1; dTraf4; TRAF; traf-1/4; traf-4; traf1; Traf1; TRAF1; traf1/4; traf4; TRAF4
Summary: Predicted to enable signaling adaptor activity. Involved in several processes, including asymmetric protein localization involved in cell fate determination; gastrulation; and imaginal disc fusion, thorax closure. Located in apical cortex. Is expressed in several structures, including CNS glial cell; anlage in statu nascendi; ganglia; head epidermis primordium; and unpaired neurons. Orthologous to human TRAF4 (TNF receptor associated factor 4). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 24E1-24E4; 2-12 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (4361925..4380716)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (4361925..4380716)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rbf1-induced apoptosis activates a compensatory proliferation mechanism which also depends on Slipper and TRAF1, indicating that these two proteins seem to be key players of compensatory proliferation in Drosophila.
Title: Two different specific JNK activators are required to trigger apoptosis or compensatory proliferation in response to Rbf1 in Drosophila.
Traf4 is expressed throughout development, and is required for efficient apical constrictions of ventral furrow cells.
Title: Role for Traf4 in polarizing adherens junctions as a prerequisite for efficient cell shape changes.
Expression of Reaper leads to a loss of DIAP1 inhibition of DTRAF1-mediated JNK activation in Drosophila cells.
Title: Reaper-mediated inhibition of DIAP1-induced DTRAF1 degradation results in activation of JNK in Drosophila.
DTRAF1-null mutant showed a remarkable reduction in JNK activity with an impaired development of imaginal discs and a defective formation of photosensory neuron arrays.
Title: Discrete functions of TRAF1 and TRAF2 in Drosophila melanogaster mediated by c-Jun N-terminal kinase and NF-kappaB-dependent signaling pathways.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0180 (e-PCR)
- UniSTS:77124

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in activation of NF-kappaB-inducing kinase activity	IEA Inferred from Electronic Annotation more info
involved_in adherens junction organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apical constriction involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in asymmetric protein localization involved in cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure	TAS Traceable Author Statement more info	PubMed
involved_in eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc fusion, thorax closure	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of JNK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of JNK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in ventral furrow formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical cortex	IDA Inferred from Direct Assay more info	PubMed
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of plasma membrane signaling receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: TNF-receptor-associated factor 4

Names: CG3048-PA; CG3048-PE; TNF receptor associated factor 1; TNF receptor associated factor 4; TNF-receptor associated factor 4; TNF-receptor-associated factor 1; Traf4-PA; Traf4-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

4361925..4380716

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001103610.2 → NP_001097080.2 TNF-receptor-associated factor 4, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097080.2

Status: REVIEWED

UniProtKB/TrEMBL

A8DYU9, Q9UAC5

Conserved Domains (2) summary

cd03781
Location:322 → 470

MATH_TRAF4; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF4 subfamily, TRAF domain, C-terminal MATH subdomain; composed of proteins with similarity to human TRAF4, including the Drosophila protein DTRAF1. TRAF molecules serve as adapter ...

pfam02176
Location:224 → 283

zf-TRAF; TRAF-type zinc finger
NM_058068.4 → NP_477416.1 TNF-receptor-associated factor 4, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477416.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9UAC5, Q9XYR0

Related

FBpp0077119

Conserved Domains (3) summary

PLN03086
Location:109 → 206

PLN03086; PRLI-interacting factor K; Provisional

cd03781
Location:331 → 479

MATH_TRAF4; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF4 subfamily, TRAF domain, C-terminal MATH subdomain; composed of proteins with similarity to human TRAF4, including the Drosophila protein DTRAF1. TRAF molecules serve as adapter ...

cl40617
Location:233 → 292

zf-TRAF; TRAF-type zinc finger