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sox4a - SRY-box transcription factor 4a

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within closure of optic fissure and negative regulation of smoothened signaling pathway. Predicted to be active in nucleus. Is expressed in several structures, including anterior neural rod; digestive system; nervous system; neural tube; and periderm. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 10 and urinary bladder cancer. Orthologous to human SOX4 (SRY-box transcription factor 4). [provided by Alliance of Genome Resources, Dec 2024]

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Species Gene Architecture aa