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rho4 Rho family GTPase Rho4 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 3361476, updated on 18-Sep-2024

Summary

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Official Symbol
rho4
Official Full Name
Rho family GTPase Rho4
Primary source
PomBase:SPAC16A10.04
Locus tag
SPOM_SPAC16A10.04
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See rho4 in Genome Data Viewer
Location:
chromosome: I
Exon count:
6
Sequence:
Chromosome: I; NC_003424.3 (3087013..3088619)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene tRNA-Lys Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DASH complex subunit Dad1 Neighboring gene Smc5-6 complex non-SMC SUMO ligase subunit Nse2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Novel Rho GTPase involved in cytokinesis and cell wall integrity in the fission yeast Schizosaccharomyces pombe. Santos B, et al. Eukaryot Cell, 2003 Jun. PMID 12796297, Free PMC Article
  2. Septum formation is regulated by the RHO4-specific exchange factors BUD3 and RGF3 and by the landmark protein BUD4 in Neurospora crassa. Justa-Schuch D, et al. Mol Microbiol, 2010 Apr. PMID 20199606
  3. Rho4 GTPase is involved in secretion of glucanases during fission yeast cytokinesis. Santos B, et al. Eukaryot Cell, 2005 Oct. PMID 16215171, Free PMC Article
  4. The small GTPase Rho4 is involved in controlling cell morphology and septation in fission yeast. Nakano K, et al. Genes Cells, 2003 Apr. PMID 12653963
  5. Geranylgeranyltransferase Cwg2-Rho4/Rho5 module is implicated in the Pmk1 MAP kinase-mediated cell wall integrity pathway in fission yeast. Doi A, et al. Genes Cells, 2015 Apr. PMID 25651781

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that Rho guanine nucleotide exchange factors Gef3 interacts with the septin complex and activates Rho4 GTPase for septation during cytokinesis.
    Title: The Rho-GEF Gef3 interacts with the septin complex and activates the GTPase Rho4 during fission yeast cytokinesis.
  2. Rho4 and Rho5 deletion cells exhibited the vic phenotype and cell wall integrity defects, shared phenotypes among the components of the Pmk1 MAPK pathway.
    Title: Geranylgeranyltransferase Cwg2-Rho4/Rho5 module is implicated in the Pmk1 MAP kinase-mediated cell wall integrity pathway in fission yeast.
  3. These results provide evidence that Rho4p is involved in the regulation of Eng1p and Agn1p secretion during cytokinesis.
    Title: Rho4 GTPase is involved in secretion of glucanases during fission yeast cytokinesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in division septum assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fungal-type cell wall organization or biogenesis TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of septum digestion after cytokinesis EXP
Inferred from Experiment
more info
 PubMed 
involved_in primary cell septum disassembly TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cell division site EXP
Inferred from Experiment
more info
 PubMed 
is_active_in cytoplasmic side of plasma membrane NAS
Non-traceable Author Statement
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in division septum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Rho family GTPase Rho4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    3087013..3088619
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019469.3 → NP_001018257.1  Rho family GTPase Rho4 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_001018257.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q874R1
    Conserved Domains (2) summary
    smart00174
    Location:17 → 185
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
    cd04132
    Location:12 → 189
    Rho4_like; Ras homology family 4 (Rho4) of small guanosine triphosphatases (GTPases)-like
Nucleotide Protein
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