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csn2 COP9/signalosome complex subunit Csn2 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 3361420, updated on 18-Sep-2024

Summary

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Official Symbol
csn2
Official Full Name
COP9/signalosome complex subunit Csn2
Primary source
PomBase:SPAPB17E12.04c
Locus tag
SPOM_SPAPB17E12.04C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See csn2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
5
Sequence:
Chromosome: I; NC_003424.3 (1272557..1274536, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene SMN complex subunit Yip12/Gem2 Neighboring gene ubiquitin-protein ligase E3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 60S ribosomal protein eL37 Neighboring gene protein sos7

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Deletion mutants in COP9/signalosome subunits in fission yeast Schizosaccharomyces pombe display distinct phenotypes. Mundt KE, et al. Mol Biol Cell, 2002 Feb. PMID 11854407, Free PMC Article
  2. Basis for metabolite-dependent Cullin-RING ligase deneddylation by the COP9 signalosome. Lin H, et al. Proc Natl Acad Sci U S A, 2020 Feb 25. PMID 32047038, Free PMC Article
  3. Transactivation of Schizosaccharomyces pombe cdt2+ stimulates a Pcu4-Ddb1-CSN ubiquitin ligase. Liu C, et al. EMBO J, 2005 Nov 16. PMID 16252005, Free PMC Article
  4. CAND1 controls in vivo dynamics of the cullin 1-RING ubiquitin ligase repertoire. Wu S, et al. Nat Commun, 2013. PMID 23535663, Free PMC Article
  5. Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. Lyapina S, et al. Science, 2001 May 18. PMID 11337588

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables inositol hexakisphosphate binding EXP
Inferred from Experiment
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein deneddylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein deneddylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of COP9 signalosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol HDA PubMed 
is_active_in nucleus HDA PubMed 

General protein information

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Preferred Names
COP9/signalosome complex subunit Csn2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    1272557..1274536 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018700.3 → NP_001018220.1  COP9/signalosome complex subunit Csn2 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_001018220.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q9HFR0
    Conserved Domains (2) summary
    COG5159
    Location:48 → 418
    RPN6; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
    pfam01399
    Location:311 → 415
    PCI; PCI domain
Nucleotide Protein
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