slp1 sloppy paired 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: slp1provided by FlyBase
Official Full Name: sloppy paired 1provided by FlyBase
Primary source: FLYBASE:FBgn0003430
Locus tag: Dmel_CG16738
See related: AllianceGenome:FB:FBgn0003430
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG16738; Dmel\CG16738; Dmslp1; FD6; FoxG; l(2)05965; sko1; Sloppy-paired; slp; Slp; SLP; slp 1; slp-1; Slp-1; slp-2; Slp1; SLP1
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in heart formation; negative regulation of transcription by RNA polymerase II; and specification of segmental identity, head. Located in nucleus. Is expressed in several structures, including anlage in statu nascendi; circulatory system primordium; proventriculus; segment; and somatic precursor cell. Orthologous to human FOXG1 (forkhead box G1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (3825675..3827099)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (3825675..3827099)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anatomical structure morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in anterior/posterior axis specification, embryo	NAS Non-traceable Author Statement more info	PubMed
involved_in blastoderm segmentation	TAS Traceable Author Statement more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in heart development	TAS Traceable Author Statement more info	PubMed
involved_in heart formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesoderm formation	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in specification of segmental identity, head	IEP Inferred from Expression Pattern more info	PubMed
involved_in specification of segmental identity, head	IGI Inferred from Genetic Interaction more info	PubMed
involved_in specification of segmental identity, head	IMP Inferred from Mutant Phenotype more info	PubMed