Shaw Shaker cognate w [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Shawprovided by FlyBase
Official Full Name: Shaker cognate wprovided by FlyBase
Primary source: FLYBASE:FBgn0003386
Locus tag: Dmel_CG2822
See related: AllianceGenome:FB:FBgn0003386
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG15419; CG2822; Dmel\CG2822; dShaw; dShaw2; Kv3; Kv3.1; K[[v]]3; shaw; Shaw2
Summary: Predicted to enable delayed rectifier potassium channel activity. Involved in sleep. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in several cellular components, including dendrite membrane; neuronal cell body membrane; and synaptic membrane. Is expressed in several structures, including LN period neurons; adult descending neurons; and adult head. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 103; progressive myoclonus epilepsy 7; and spinocerebellar ataxia type 13. Orthologous to several human genes including KCNC1 (potassium voltage-gated channel subfamily C member 1); KCNC2 (potassium voltage-gated channel subfamily C member 2); and KCNC4 (potassium voltage-gated channel subfamily C member 4). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 24C1-24C2; 2-11 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (3718185..3729145)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (3718185..3729145)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

increasing Shaw levels in all clock neurons (LNv, LNd, DN(1), DN(2) and DN(3)), or in subsets of clock neurons (LNd and DNs or DNs alone) increases locomotor activity at night
Title: Function of the Shaw potassium channel within the Drosophila circadian clock.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables delayed rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated monoatomic cation channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables voltage-gated potassium channel activity	IEA Inferred from Electronic Annotation more info
enables voltage-gated potassium channel activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in potassium ion transport	TAS Traceable Author Statement more info	PubMed
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info
involved_in sleep	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in axon terminus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in dendrite membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuronal cell body membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IEA Inferred from Electronic Annotation more info
part_of voltage-gated potassium channel complex	ISS Inferred from Sequence or Structural Similarity more info
part_of voltage-gated potassium channel complex	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: shaker cognate w

Names: CG2822-PA; CG2822-PB; CG2822-PC; CG2822-PD; CG2822-PE; Shaw-PA; Shaw-PB; Shaw-PC; Shaw-PD; Shaw-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

3718185..3729145

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001273072.1 → NP_001260001.1 shaker cognate w, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260001.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PEE2

Conserved Domains (4) summary

smart00225
Location:12 → 110

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00520
Location:229 → 424

Ion_trans; Ion transport protein

pfam02214
Location:12 → 102

BTB_2; BTB/POZ domain

pfam07885
Location:340 → 414

Ion_trans_2; Ion channel
NM_001273071.1 → NP_001260000.1 shaker cognate w, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260000.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PC22

Conserved Domains (2) summary

cd18416
Location:9 → 120

BTB_Shaw-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel protein Shaw

pfam00520
Location:173 → 424

Ion_trans; Ion transport protein
NM_057373.3 → NP_476721.1 shaker cognate w, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476721.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P17972, Q9VQU5

Related

FBpp0088331

Conserved Domains (2) summary

cd18416
Location:9 → 120

BTB_Shaw-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel protein Shaw

pfam00520
Location:173 → 424

Ion_trans; Ion transport protein
NM_164554.3 → NP_722937.2 shaker cognate w, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_722937.2

Status: REVIEWED

UniProtKB/TrEMBL

Q8SYL2, Q9VQU6

Related

FBpp0088332

Conserved Domains (4) summary

smart00225
Location:12 → 110

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00520
Location:229 → 424

Ion_trans; Ion transport protein

pfam02214
Location:12 → 102

BTB_2; BTB/POZ domain

pfam07885
Location:340 → 414

Ion_trans_2; Ion channel
NM_001144310.1 → NP_001137782.1 shaker cognate w, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001137782.1

Status: REVIEWED

UniProtKB/TrEMBL

B7Z009

Conserved Domains (4) summary

smart00225
Location:27 → 125

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00520
Location:244 → 439

Ion_trans; Ion transport protein

pfam02214
Location:27 → 117

BTB_2; BTB/POZ domain

pfam07885
Location:355 → 429

Ion_trans_2; Ion channel