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man1a2 mannosidase, alpha, class 1A, member 2 [ Danio rerio (zebrafish) ]

Gene ID: 335538, updated on 4-Jan-2025

Summary

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Official Symbol
man1a2provided by ZNC
Official Full Name
mannosidase, alpha, class 1A, member 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-070912-390
See related
Ensembl:ENSDARG00000041728 AllianceGenome:ZFIN:ZDB-GENE-070912-390
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fj20e02; wu:fj20e02; si:dkey-174k18.8
Summary
Predicted to enable mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Acts upstream of or within determination of left/right symmetry; intrahepatic bile duct development; and regulation of cilium assembly. Predicted to be located in membrane. Predicted to be active in Golgi membrane and endoplasmic reticulum. Is expressed in liver. Orthologous to human MAN1A2 (mannosidase alpha class 1A member 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See man1a2 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (20554178..20765330)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (20743282..20954456)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene V-set domain containing T cell activation inhibitor 1 Neighboring gene tripartite motif containing 45 Neighboring gene uncharacterized LOC103911637 Neighboring gene uncharacterized LOC137496469 Neighboring gene terminal nucleotidyltransferase 5C Neighboring gene ganglioside induced differentiation associated protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Expression of the Z Variant of α1-Antitrypsin Suppresses Hepatic Cholesterol Biosynthesis in Transgenic Zebrafish. Fung C, et al. Int J Mol Sci, 2023 Jan 27. PMID 36768797, Free PMC Article
  2. Biliary-Atresia-Associated Mannosidase-1-Alpha-2 Gene Regulates Biliary and Ciliary Morphogenesis and Laterality. So J, et al. Front Physiol, 2020. PMID 33192543, Free PMC Article
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
  
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within determination of heart left/right asymmetry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within determination of liver left/right asymmetry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within determination of pancreatic left/right asymmetry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within intrahepatic bile duct development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within intrahepatic bile duct development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mannosyl-oligosaccharide 1,2-alpha-mannosidase IB
NP_001243551.1
XP_005167594.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256622.1 → NP_001243551.1  mannosyl-oligosaccharide 1,2-alpha-mannosidase IB

    See identical proteins and their annotated locations for NP_001243551.1

    Status: VALIDATED

    Source sequence(s)
    CR391919, CT573229
    UniProtKB/TrEMBL
    A0A8M1P2K5, B0V2X9
    Related
    ENSDARP00000151347.1, ENSDART00000183911.1
    Conserved Domains (1) summary
    pfam01532
    Location:191 → 630
    Glyco_hydro_47; Glycosyl hydrolase family 47

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    20554178..20765330
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005167537.5 → XP_005167594.1  mannosyl-oligosaccharide 1,2-alpha-mannosidase IB isoform X1

    See identical proteins and their annotated locations for XP_005167594.1

    UniProtKB/TrEMBL
    A0A8M1P2K5, B0V2X9
    Related
    ENSDARP00000120629.1, ENSDART00000144248.2
    Conserved Domains (1) summary
    pfam01532
    Location:191 → 630
    Glyco_hydro_47; Glycosyl hydrolase family 47
Nucleotide Protein
Heading Accession and Version

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