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CG17883 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3355139, updated on 9-Dec-2024

Summary

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Official Symbol
CG17883provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0040005
Locus tag
Dmel_CG17883
See related
AllianceGenome:FB:FBgn0040005
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG40289; Dmel\CG17883
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Located in endoplasmic reticulum. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in Warburg micro syndrome 4. Orthologous to human TBC1D20 (TBC1 domain family member 20). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG17883 in Genome Data Viewer
Location:
41B3-41B3; 2-55 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (4671853..4673639)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (559358..561144)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene downstream non-coding target of Rpd3 and Loco Neighboring gene uncharacterized protein Neighboring gene Nipped-B Neighboring gene long non-coding RNA:CR45471 Neighboring gene pseudo

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Essential loci in centromeric heterochromatin of Drosophila melanogaster. I: the right arm of chromosome 2. Coulthard AB, et al. Genetics, 2010 Jun. PMID 20382826, Free PMC Article
  2. Evolution of Tre-2/Bub2/Cdc16 (TBC) Rab GTPase-activating proteins. Gabernet-Castello C, et al. Mol Biol Cell, 2013 May. PMID 23485563, Free PMC Article
  3. Evi5 promotes collective cell migration through its Rab-GAP activity. Laflamme C, et al. J Cell Biol, 2012 Jul 9. PMID 22778279, Free PMC Article
  4. Genetic analysis of RpL38 and RpL5, two minute genes located in the centric heterochromatin of chromosome 2 of Drosophila melanogaster. Marygold SJ, et al. Genetics, 2005 Feb. PMID 15520262, Free PMC Article
  5. Adaptation of gene loci to heterochromatin in the course of Drosophila evolution is associated with insulator proteins. Funikov SY, et al. Sci Rep, 2020 Jul 17. PMID 32681087, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

  • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG17883-PA
CG17883-PB
CG17883-PC
CG17883-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    4671853..4673639
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001042984.2 → NP_001036449.1  uncharacterized protein Dmel_CG17883, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036449.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5LJQ4
    Conserved Domains (1) summary
    pfam00566
    Location:91 → 260
    RabGAP-TBC; Rab-GTPase-TBC domain

  2. NM_001042983.2 → NP_001036448.1  uncharacterized protein Dmel_CG17883, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036448.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7PLI1, Q9W5H8
    Conserved Domains (1) summary
    pfam00566
    Location:91 → 260
    RabGAP-TBC; Rab-GTPase-TBC domain

  3. NM_001273772.1 → NP_001260701.1  uncharacterized protein Dmel_CG17883, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260701.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KEC2
    Conserved Domains (1) summary
    pfam00566
    Location:91 → 260
    RabGAP-TBC; Rab-GTPase-TBC domain

  4. NM_001273773.1 → NP_001260702.1  uncharacterized protein Dmel_CG17883, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260702.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KEH8
    Conserved Domains (1) summary
    pfam00566
    Location:91 → 260
    RabGAP-TBC; Rab-GTPase-TBC domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KEC2 A0A0B4KEC2
A0A0B4KEH8 A0A0B4KEH8
Q5LJQ4 Q5LJQ4
Q9W5H8 Q9W5H8

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