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conu conundrum [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3355133, updated on 4-Jan-2025

Summary

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Official Symbol
conuprovided by FlyBase
Official Full Name
conundrumprovided by FlyBase
Primary source
FLYBASE:FBgn0039994
Locus tag
Dmel_CG17082
See related
AllianceGenome:FB:FBgn0039994
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:LD04957; CG17082; CG40286; Conu; Dmel\CG17082
Summary
Enables GTPase activator activity. Involved in positive regulation of cell population proliferation. Located in apical cortex. Is expressed in organism. Human ortholog(s) of this gene implicated in allergic disease and schizophrenia. Orthologous to human ARHGAP18 (Rho GTPase activating protein 18); ARHGAP28 (Rho GTPase activating protein 28); and ARHGAP40 (Rho GTPase activating protein 40). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See conu in Genome Data Viewer
Location:
41C1-41C1; 2-55 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (4744348..4758048)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (631853..645553)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45471 Neighboring gene pseudo Neighboring gene pseudo Neighboring gene long non-coding RNA:CR46064 Neighboring gene pseudo Neighboring gene long non-coding RNA:CR46478 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Feedback inhibition of actin on Rho mediates content release from large secretory vesicles. Segal D, et al. J Cell Biol, 2018 May 7. PMID 29496739, Free PMC Article
  2. Conundrum, an ARHGAP18 orthologue, regulates RhoA and proliferation through interactions with Moesin. Neisch AL, et al. Mol Biol Cell, 2013 May. PMID 23468526, Free PMC Article
  3. The Green Valley of Drosophila melanogaster Constitutive Heterochromatin: Protein-Coding Genes Involved in Cell Division Control. Messina G, et al. Cells, 2022 Sep 29. PMID 36231024, Free PMC Article
  4. RhoGAP19D inhibits Cdc42 laterally to control epithelial cell shape and prevent invasion. Fic W, et al. J Cell Biol, 2021 Apr 5. PMID 33646271, Free PMC Article
  5. Prepatterning by RhoGEFs governs Rho GTPase spatiotemporal dynamics during wound repair. Nakamura M, et al. J Cell Biol, 2017 Dec 4. PMID 28923977, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Moesin interacts with an unusual RhoGAP, Conundrum (Conu), and recruits it to the cell cortex to negatively regulate RhoA activity.
    Title: Conundrum, an ARHGAP18 orthologue, regulates RhoA and proliferation through interactions with Moesin.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 4748502-4748577 mobile_element_type = transposon:INE-1{}4388
  • Loc: 4750399-4751495 mobile_element_type = transposon:1360{}5000
  • Loc: 4751587-4751642 mobile_element_type = transposon:INE-1{}4391
  • Loc: 4752406-4753474 mobile_element_type = transposon:Rt1c{}5065
  • Loc: 4754933-4755362 mobile_element_type = transposon:Cr1a{}5025

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of small GTPase mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical cortex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
conundrum
Names
CG17082-PA
CG17082-PB
CG17082-PD
CG17082-PG
CG17082-PI
conu-PA
conu-PB
conu-PD
conu-PG
conu-PI

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    4744348..4758048
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001042992.2 → NP_001036457.1  conundrum, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036457.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0E9Q3, Q8T0G4
    UniProtKB/TrEMBL
    C9QP26
    Conserved Domains (1) summary
    cd04391
    Location:356 → 576
    RhoGAP_ARHGAP18; RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their ...

  2. NM_001042990.3 → NP_001036455.2  conundrum, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036455.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0E9Q3, Q8T0G4
    UniProtKB/TrEMBL
    C9QP26
    Conserved Domains (1) summary
    cd04391
    Location:356 → 576
    RhoGAP_ARHGAP18; RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their ...

  3. NM_001042989.3 → NP_001036454.1  conundrum, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036454.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0E9Q3, Q8T0G4
    UniProtKB/TrEMBL
    C9QP26
    Conserved Domains (1) summary
    cd04391
    Location:356 → 576
    RhoGAP_ARHGAP18; RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their ...

  4. NM_001042993.3 → NP_001036458.1  conundrum, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036458.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0E9Q3, Q8T0G4
    UniProtKB/TrEMBL
    C9QP26
    Conserved Domains (1) summary
    cd04391
    Location:356 → 576
    RhoGAP_ARHGAP18; RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their ...

  5. NM_001042991.3 → NP_001036456.3  conundrum, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036456.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0E9Q3, Q8T0G4
    UniProtKB/TrEMBL
    C9QP26
    Conserved Domains (1) summary
    cd04391
    Location:356 → 576
    RhoGAP_ARHGAP18; RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8T0G4.1 Q8T0G4

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