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CG17493 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3355126, updated on 4-Jan-2025

Summary

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Official Symbol
CG17493provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0040010
Locus tag
Dmel_CG17493
See related
AllianceGenome:FB:FBgn0040010
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG40016; Dmel\CG17493
Summary
Predicted to enable calcium ion binding activity. Predicted to be involved in centriole replication. Predicted to be active in centriole; centrosome; and nucleus. Is expressed in larval ventral nerve cord and organism. Orthologous to several human genes including CETN1 (centrin 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG17493 in Genome Data Viewer
Location:
40F7-40F7; 2-54 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (22550064..22556295)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (22442796..22449027)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene long non-coding RNA:CR46268 Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein L5 Neighboring gene Sarcolemma associated protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43927

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evolution of heterochromatic genes of Drosophila. Yasuhara JC, et al. Proc Natl Acad Sci U S A, 2005 Aug 2. PMID 16033869, Free PMC Article
  2. The Green Valley of Drosophila melanogaster Constitutive Heterochromatin: Protein-Coding Genes Involved in Cell Division Control. Messina G, et al. Cells, 2022 Sep 29. PMID 36231024, Free PMC Article
  3. The Recent De Novo Origin of Protein C-Termini. Andreatta ME, et al. Genome Biol Evol, 2015 May 21. PMID 26002864, Free PMC Article
  4. A Balance of Yki/Sd Activator and E2F1/Sd Repressor Complexes Controls Cell Survival and Affects Organ Size. Zhang P, et al. Dev Cell, 2017 Dec 4. PMID 29207260, Free PMC Article
  5. Thirteen is enough: the myosins of Dictyostelium discoideum and their light chains. Kollmar M. BMC Genomics, 2006 Jul 20. PMID 16857047, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

  • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in centriole replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG17493-PB
CG17493-PC
CG17493-PD
CentrinB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    22550064..22556295
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273763.1 → NP_001260692.1  uncharacterized protein Dmel_CG17493, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260692.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PGG8
    Conserved Domains (2) summary
    PTZ00183
    Location:26 → 182
    PTZ00183; centrin; Provisional
    cd00051
    Location:115 → 177
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  2. NM_001273764.1 → NP_001260693.1  uncharacterized protein Dmel_CG17493, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260693.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PGG8
    Conserved Domains (2) summary
    PTZ00183
    Location:26 → 182
    PTZ00183; centrin; Provisional
    cd00051
    Location:115 → 177
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  3. NM_001042931.3 → NP_001036396.2  uncharacterized protein Dmel_CG17493, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036396.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PGG8
    Conserved Domains (2) summary
    PTZ00183
    Location:26 → 182
    PTZ00183; centrin; Provisional
    cd00051
    Location:115 → 177
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PGG8 M9PGG8
Q8SXJ8 Q8SXJ8

Gene LinkOut

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