FASN3 Fatty acid synthase 3 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: FASN3provided by FlyBase
Official Full Name: Fatty acid synthase 3provided by FlyBase
Primary source: FLYBASE:FBgn0287184
Locus tag: Dmel_CG17374
See related: AllianceGenome:FB:FBgn0287184
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 80Ff; CG17374; Dmel\CG17374; DM_7289423; FAS; fasn3; FASN[CG17374]; FAS[CG17374]; l(3)80Ff; l(3)Lh4B; l4B
Summary: Predicted to enable [acyl-carrier-protein] S-acetyltransferase activity and fatty acid synthase activity. Predicted to be involved in fatty acid biosynthetic process. Is expressed in adult head; adult heart; adult oenocyte; and spermatozoon. Orthologous to human FASN (fatty acid synthase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 80F9-80F9; 3-47 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (25752859..25762779, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3LHet	NW_001848857.1 (1135558..1145478, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables 3-oxoacyl-[acyl-carrier-protein] synthase activity	IEA Inferred from Electronic Annotation more info
enables [acyl-carrier-protein] S-acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables fatty acid synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables phosphopantetheine binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: fatty acid synthase 3

Names: CG17374-PC; FASN3-PC; lethal (3) 80Ff; lethal 4B; lethal4B

NP_001015405.3

EC 1.-.-.-

EC 2.-.-.-

EC 2.3.-.-

EC 2.3.1.38

EC 2.3.1.41

EC 2.3.1.85

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

25752859..25762779 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001015405.4 → NP_001015405.3 fatty acid synthase 3 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001015405.3

Status: REVIEWED

UniProtKB/TrEMBL

Q7PLB8

Conserved Domains (12) summary

cd05195
Location:1443 → 1734

enoyl_red; enoyl reductase of polyketide synthase

cd08954
Location:1761 → 1988

KR_1_FAS_SDR_x; beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 1, complex (x) SDRs

smart00823
Location:2000 → 2067

PKS_PP; Phosphopantetheine attachment site

smart00825
Location:21 → 421

PKS_KS; Beta-ketoacyl synthase

smart00829
Location:1443 → 1734

PKS_ER; Enoylreductase

COG0596
Location:2120 → 2371

MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

cd00833
Location:19 → 421

PKS; polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or ...

pfam16197
Location:383 → 492

KAsynt_C_assoc; Ketoacyl-synthetase C-terminal extension

cl00509
Location:877 → 1076

hot_dog; The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated ...

cl08282
Location:517 → 831

Acyl_transf_1; Acyl transferase domain

cl21454
Location:1301 → 1411

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

cl21494
Location:2120 → 2375

Abhydrolase; alpha/beta hydrolases