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FASN3 Fatty acid synthase 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3355111, updated on 9-Dec-2024

Summary

Official Symbol
FASN3provided by FlyBase
Official Full Name
Fatty acid synthase 3provided by FlyBase
Primary source
FLYBASE:FBgn0287184
Locus tag
Dmel_CG17374
See related
AllianceGenome:FB:FBgn0287184
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
80Ff; CG17374; Dmel\CG17374; DM_7289423; FAS; fasn3; FASN[CG17374]; FAS[CG17374]; l(3)80Ff; l(3)Lh4B; l4B
Summary
Predicted to enable [acyl-carrier-protein] S-acetyltransferase activity and fatty acid synthase activity. Predicted to be involved in fatty acid biosynthetic process. Is expressed in adult head; adult heart; adult oenocyte; and spermatozoon. Orthologous to human FASN (fatty acid synthase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See FASN3 in Genome Data Viewer
Location:
80F9-80F9; 3-47 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (25752859..25762779, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3LHet NW_001848857.1 (1135558..1145478, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene loss of visual transmission Neighboring gene pseudo Neighboring gene long non-coding RNA:CR45180 Neighboring gene antisense RNA:CR45182 Neighboring gene lethal (3) 80Fg Neighboring gene pseudo

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

  • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 3-oxoacyl-[acyl-carrier-protein] synthase activity IEA
Inferred from Electronic Annotation
more info
 
enables [acyl-carrier-protein] S-acetyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables fatty acid synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphopantetheine binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
fatty acid synthase 3
Names
CG17374-PC
FASN3-PC
lethal (3) 80Ff
lethal 4B
lethal4B
NP_001015405.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    25752859..25762779 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001015405.4NP_001015405.3  fatty acid synthase 3 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001015405.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7PLB8
    Conserved Domains (12) summary
    cd05195
    Location:14431734
    enoyl_red; enoyl reductase of polyketide synthase
    cd08954
    Location:17611988
    KR_1_FAS_SDR_x; beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 1, complex (x) SDRs
    smart00823
    Location:20002067
    PKS_PP; Phosphopantetheine attachment site
    smart00825
    Location:21421
    PKS_KS; Beta-ketoacyl synthase
    smart00829
    Location:14431734
    PKS_ER; Enoylreductase
    COG0596
    Location:21202371
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    cd00833
    Location:19421
    PKS; polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or ...
    pfam16197
    Location:383492
    KAsynt_C_assoc; Ketoacyl-synthetase C-terminal extension
    cl00509
    Location:8771076
    hot_dog; The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated ...
    cl08282
    Location:517831
    Acyl_transf_1; Acyl transferase domain
    cl21454
    Location:13011411
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    cl21494
    Location:21202375
    Abhydrolase; alpha/beta hydrolases