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Alg-2 Apoptosis-linked gene-2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3355106, updated on 4-Jan-2025

Summary

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Official Symbol
Alg-2provided by FlyBase
Official Full Name
Apoptosis-linked gene-2provided by FlyBase
Primary source
FLYBASE:FBgn0086378
Locus tag
Dmel_CG40410
See related
AllianceGenome:FB:FBgn0086378
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ALG-2; CG17661; CG40410; DALG-2; Dmel\CG40410
Summary
Predicted to enable calcium ion binding activity. Involved in positive regulation of JNK cascade. Is expressed in organism. Orthologous to human PDCD6 (programmed cell death 6). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Alg-2 in Genome Data Viewer
Location:
81F5-81F5; 3-47.1 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (3623143..3627690)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3RHet NW_001848858.1 (1894569..1899116, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene spookier Neighboring gene Poly-(ADP-ribose) polymerase 1 Neighboring gene long non-coding RNA:CR46141 Neighboring gene Translocase of the inner mitochondrial membrane 17b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. POSH, a scaffold protein for JNK signaling, binds to ALG-2 and ALIX in Drosophila. Tsuda M, et al. FEBS Lett, 2006 May 29. PMID 16698022
  2. A novel regulator of ER Ca(2+) drives Hippo-mediated tumorigenesis. Ma X, et al. Oncogene, 2020 Feb. PMID 31649333
  3. Genes expressed in the Drosophila head reveal a role for fat cells in sex-specific physiology. Fujii S, et al. EMBO J, 2002 Oct 15. PMID 12374736, Free PMC Article
  4. The Organization of Pericentromeric Heterochromatin in Polytene Chromosome 3 of the Drosophilamelanogaster Line with the Rif1(1); SuUR(ES) Su(var)3-9(06) Mutations Suppressing Underreplication. Zykova T, et al. Cells, 2021 Oct 20. PMID 34831030, Free PMC Article
  5. A library of MiMICs allows tagging of genes and reversible, spatial and temporal knockdown of proteins in Drosophila. Nagarkar-Jaiswal S, et al. Elife, 2015 Mar 31. PMID 25824290, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

  • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of JNK cascade IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Apoptosis-linked gene-2
Names
Alg-2-PC
CG40410-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    3623143..3627690
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001110989.3 → NP_001104459.2  Apoptosis-linked gene-2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001104459.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8Y589
    Conserved Domains (2) summary
    cd00051
    Location:85 → 139
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam13499
    Location:82 → 139
    EF-hand_7; EF-hand domain pair
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8Y589 A8Y589
Q8SYT2 Q8SYT2

Gene LinkOut

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