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RpL15 Ribosomal protein L15 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3354918, updated on 4-Jan-2025

Summary

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Official Symbol
RpL15provided by FlyBase
Official Full Name
Ribosomal protein L15provided by FlyBase
Primary source
FLYBASE:FBgn0028697
Locus tag
Dmel_CG17420
See related
AllianceGenome:FB:FBgn0028697
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
80Fi; CG17420; CG40199; Dmel\CG17420; DmRpL15; l(3)80Fi; l(3)Lh2; L15; L15e; l2; lethal 2; rpl15; rpL15; Rpl15; RPL15
Summary
A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Located in cytosolic ribosome. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 12. Orthologous to human RPL15 (ribosomal protein L15). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See RpL15 in Genome Data Viewer
Location:
80F9-80F9; 3-47 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (27267255..27268445)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3LHet NW_001848857.1 (2397791..2398981)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA Me18S-G1358c Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene verthandi Neighboring gene long non-coding RNA:CR46250 Neighboring gene Dead box protein 80 Neighboring gene long non-coding RNA:CR46482 Neighboring gene pseudo Neighboring gene eukaryotic translation initiation factor 4B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Heterochromatin protein 1 (HP1) modulates replication timing of the Drosophila genome. Schwaiger M, et al. Genome Res, 2010 Jun. PMID 20435908, Free PMC Article
  2. Characterization of Gfat1 (zeppelin) and Gfat2, Essential Paralogous Genes Which Encode the Enzymes That Catalyze the Rate-Limiting Step in the Hexosamine Biosynthetic Pathway in Drosophila melanogaster. Cotsworth S, et al. Cells, 2022 Jan 27. PMID 35159258, Free PMC Article
  3. Effects of Mutations in the Drosophila melanogaster Rif1 Gene on the Replication and Underreplication of Pericentromeric Heterochromatin in Salivary Gland Polytene Chromosomes. Kolesnikova TD, et al. Cells, 2020 Jun 19. PMID 32575592, Free PMC Article
  4. Highly efficient genome modifications mediated by CRISPR/Cas9 in Drosophila. Yu Z, et al. Genetics, 2013 Sep. PMID 23833182, Free PMC Article
  5. A genetic and molecular characterization of two proximal heterochromatic genes on chromosome 3 of Drosophila melanogaster. Schulze SR, et al. Genetics, 2005 Apr. PMID 15687284, Free PMC Article

See all (74) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

  • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of ribosome TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoplasmic translation IC
Inferred by Curator
more info
 PubMed 
involved_in cytoplasmic translation TAS
Traceable Author Statement
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit TAS
Traceable Author Statement
more info
 PubMed 
located_in cytosolic ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ribosomal protein L15
Names
CG17420-PA
CG17420-PB
CG17420-PC
CG17420-PE
CG17420-PF
CG17420-PG
CG17420-PH
CG17420-PI
RpL15-PA
RpL15-PB
RpL15-PC
RpL15-PE
RpL15-PF
RpL15-PG
RpL15-PH
RpL15-PI
lethal (3) 80Fi
lethal 2
lethal2
ribosomal L15

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    27267255..27268445
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001258469.1 → NP_001245398.1  ribosomal protein L15, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245398.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8Y561, O17445, Q7PL86, Q9W5N1
    UniProtKB/TrEMBL
    A8Y560
    Conserved Domains (1) summary
    pfam00827
    Location:2 → 191
    Ribosomal_L15e; Ribosomal L15

  2. NM_001258468.1 → NP_001245397.1  ribosomal protein L15, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245397.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8Y561, O17445, Q7PL86, Q9W5N1
    UniProtKB/TrEMBL
    A8Y560
    Conserved Domains (1) summary
    pfam00827
    Location:2 → 191
    Ribosomal_L15e; Ribosomal L15

  3. NM_001258466.1 → NP_001245395.1  ribosomal protein L15, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245395.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8Y561, O17445, Q7PL86, Q9W5N1
    UniProtKB/TrEMBL
    A8Y560
    Conserved Domains (1) summary
    pfam00827
    Location:2 → 191
    Ribosomal_L15e; Ribosomal L15

  4. NM_001258467.1 → NP_001245396.1  ribosomal protein L15, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245396.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8Y561, O17445, Q7PL86, Q9W5N1
    UniProtKB/TrEMBL
    A8Y560
    Conserved Domains (1) summary
    pfam00827
    Location:2 → 191
    Ribosomal_L15e; Ribosomal L15

  5. NM_001015156.2 → NP_001015156.1  ribosomal protein L15, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001015156.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8Y561, O17445, Q7PL86, Q9W5N1
    UniProtKB/TrEMBL
    A8Y560
    Conserved Domains (1) summary
    pfam00827
    Location:2 → 191
    Ribosomal_L15e; Ribosomal L15

  6. NM_001110959.3 → NP_001104429.2  ribosomal protein L15, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001104429.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8Y561, O17445, Q7PL86, Q9W5N1
    UniProtKB/TrEMBL
    A8Y560
    Conserved Domains (1) summary
    pfam00827
    Location:2 → 191
    Ribosomal_L15e; Ribosomal L15

  7. NM_001110960.2 → NP_001104430.1  ribosomal protein L15, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001104430.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8Y561, O17445, Q7PL86, Q9W5N1
    UniProtKB/TrEMBL
    A8Y560
    Conserved Domains (1) summary
    pfam00827
    Location:2 → 191
    Ribosomal_L15e; Ribosomal L15

  8. NM_001015155.3 → NP_001015155.1  ribosomal protein L15, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001015155.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8Y561, O17445, Q7PL86, Q9W5N1
    UniProtKB/TrEMBL
    A8Y560
    Conserved Domains (1) summary
    pfam00827
    Location:2 → 191
    Ribosomal_L15e; Ribosomal L15
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8Y560 A8Y560
O17445.1 O17445

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