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ccnc cyclin C [ Danio rerio (zebrafish) ]

Gene ID: 335429, updated on 9-Dec-2024

Summary

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Official Symbol
ccncprovided by ZNC
Official Full Name
cyclin Cprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-7369
See related
Ensembl:ENSDARG00000009607 AllianceGenome:ZFIN:ZDB-GENE-030131-7369
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fj11d06; zgc:73078; wu:fj11d06
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Acts upstream of or within podocyte development. Predicted to be part of mediator complex. Predicted to be active in nucleus. Orthologous to human CCNC (cyclin C). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See ccnc in Genome Data Viewer
Location:
chromosome: 4
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (5764486..5775467, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (5755916..5766897, complement)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene POU class 3 homeobox 2a Neighboring gene failed axon connections homolog, metaxin like GST domain containing a Neighboring gene notochord granular surface Neighboring gene phosphoglucomutase 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Lmx1b and FoxC combinatorially regulate podocin expression in podocytes. He B, et al. J Am Soc Nephrol, 2014 Dec. PMID 24854274, Free PMC Article
  2. Conserved regulation of p53 network dosage by microRNA-125b occurs through evolving miRNA-target gene pairs. Le MT, et al. PLoS Genet, 2011 Sep. PMID 21935352, Free PMC Article
  3. Pou3f transcription factor expression during embryonic development highlights distinct pou3f3 and pou3f4 localization in the Xenopus laevis kidney. Cosse-Etchepare C, et al. Int J Dev Biol, 2018. PMID 29877572
  4. Knockout of mafba Causes Inner-Ear Developmental Defects in Zebrafish via the Impairment of Proliferation and Differentiation of Ionocyte Progenitor Cells. Chen X, et al. Biomedicines, 2021 Nov 16. PMID 34829928, Free PMC Article
  5. Selection of reliable biomarkers from PCR array analyses using relative distance computational model: methodology and proof-of-concept study. Liu C, et al. PLoS One, 2013. PMID 24349563, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within podocyte development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cyclin-C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199951.2 → NP_956245.1  cyclin-C

    See identical proteins and their annotated locations for NP_956245.1

    Status: PROVISIONAL

    Source sequence(s)
    AY450302
    UniProtKB/TrEMBL
    Q6STL0
    Related
    ENSDARP00000017380.7, ENSDART00000021753.8
    Conserved Domains (2) summary
    cd00043
    Location:48 → 99
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
    pfam16899
    Location:154 → 241
    Cyclin_C_2; Cyclin C-terminal domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    5764486..5775467 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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