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srsf5a serine and arginine rich splicing factor 5a [ Danio rerio (zebrafish) ]

Gene ID: 335396, updated on 9-Dec-2024

Summary

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Official Symbol
srsf5aprovided by ZNC
Official Full Name
serine and arginine rich splicing factor 5aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-7336
See related
Ensembl:ENSDARG00000029818 AllianceGenome:ZFIN:ZDB-GENE-030131-7336
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sfrs5; sfrs5a; fb49e01; zgc:77797; im:6906390; wu:fb49e01; wu:fj09b12
Summary
Predicted to enable mRNA binding activity. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm and nucleus. Is expressed in nervous system; otic vesicle; pectoral fin; pharyngeal arch; and solid lens vesicle. Orthologous to human SRSF5 (serine and arginine rich splicing factor 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See srsf5a in Genome Data Viewer
Location:
chromosome: 13
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (36530230..36535067, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (36404398..36409318, complement)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene ddb1 and cul4 associated factor 5 Neighboring gene phosphofurin acidic cluster sorting protein 2 Neighboring gene deubiquitinase DESI2 Neighboring gene synaptojanin 2 binding protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Pervasive changes of mRNA splicing in upf1-deficient zebrafish identify rpl10a as a regulator of T cell development. Lawir DF, et al. Proc Natl Acad Sci U S A, 2020 Jul 7. PMID 32571908, Free PMC Article
  2. A transgenic zebrafish model expressing KIT-D816V recapitulates features of aggressive systemic mastocytosis. Balci TB, et al. Br J Haematol, 2014 Oct. PMID 24989799
  3. Number of inadvertent RNA targets for morpholino knockdown in Danio rerio is largely underestimated: evidence from the study of Ser/Arg-rich splicing factors. Joris M, et al. Nucleic Acids Res, 2017 Sep 19. PMID 28934490, Free PMC Article
  4. Genomewide expression analysis in zebrafish mind bomb alleles with pancreas defects of different severity identifies putative Notch responsive genes. Hegde A, et al. PLoS One, 2008 Jan 23. PMID 18213387, Free PMC Article
  5. The earliest transcribed zygotic genes are short, newly evolved, and different across species. Heyn P, et al. Cell Rep, 2014 Jan 30. PMID 24440719

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC77797

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine and arginine rich splicing factor 5a
Names
serine/arginine-rich splicing factor 5a
splicing factor, arginine/serine-rich 5
splicing factor, arginine/serine-rich 5a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200867.1 → NP_957161.1  serine and arginine rich splicing factor 5a

    See identical proteins and their annotated locations for NP_957161.1

    Status: PROVISIONAL

    Source sequence(s)
    AY398417
    UniProtKB/TrEMBL
    A0A8M1PBW4, Q6TGT9
    Related
    ENSDARP00000043311.3, ENSDART00000043312.5
    Conserved Domains (2) summary
    cd12337
    Location:5 → 72
    RRM1_SRSF4_like; RNA recognition motif 1 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
    cd12600
    Location:113 → 184
    RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    36530230..36535067 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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