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GABPI beta4GalNAcTB pilot [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33516, updated on 9-Dec-2024

Summary

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Official Symbol
GABPIprovided by FlyBase
Official Full Name
beta4GalNAcTB pilotprovided by FlyBase
Primary source
FLYBASE:FBgn0031495
Locus tag
Dmel_CG17257
See related
AllianceGenome:FB:FBgn0031495
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG17257; Dmel\CG17257
Summary
Predicted to enable protein-cysteine S-palmitoyltransferase activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Located in Golgi apparatus. Is expressed in several structures, including adult head; brain; central nervous system; embryonic/larval gut; and endoderm. Orthologous to human ZDHHC23 (zinc finger DHHC-type palmitoyltransferase 23). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See GABPI in Genome Data Viewer
Location:
23C5-23C5; 2-8 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3030539..3032300)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3030539..3032300)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene alpha1,4-galactosyltransferase 1 Neighboring gene pre-mRNA processing factor 40 Neighboring gene Splicing factor 3b subunit 2 Neighboring gene antisense RNA:CR44147 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Seryl-tRNA synthetase Neighboring gene uncharacterized protein Neighboring gene cornichon related

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Golgi targeting of Drosophila melanogaster beta4GalNAcTB requires a DHHC protein family-related protein as a pilot. Johswich A, et al. J Cell Biol, 2009 Jan 12. PMID 19139268, Free PMC Article
  2. "Add-on" domains of Drosophila β1,4-N-acetylgalactosaminyltransferase B in the stem region and its pilot protein. Kraft B, et al. Cell Mol Life Sci, 2011 Dec. PMID 21598021, Free PMC Article
  3. The S-palmitoylome and DHHC-PAT interactome of Drosophila melanogaster S2R+ cells indicate a high degree of conservation to mammalian palmitoylomes. Porcellato E, et al. PLoS One, 2022. PMID 35960718, Free PMC Article
  4. Gain of function screen of PATs reveals an essential role of Hip14 in Drosophila host defense. Deng Z, et al. J Genet Genomics, 2023 Dec. PMID 37343788
  5. The Drosophila protein palmitoylome: characterizing palmitoyl-thioesterases and DHHC palmitoyl-transferases. Bannan BA, et al. Fly (Austin), 2008 Jul-Aug. PMID 18719403, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lumenal loop regions are insect-conserved and essential for GABPI-b4GalNAcTB interaction.
    Title: "Add-on" domains of Drosophila β1,4-N-acetylgalactosaminyltransferase B in the stem region and its pilot protein.
  2. beta4GalNAcTB pilot (GABPI) is required for ER export and activity of beta4GalNAcTB.
    Title: Golgi targeting of Drosophila melanogaster beta4GalNAcTB requires a DHHC protein family-related protein as a pilot.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables palmitoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-cysteine S-palmitoyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
beta4GalNAcTB pilot
Names
CG17257-PA
CG17257-PB
CG17257-PC
CG17257-PD
GABPI-PA
GABPI-PB
GABPI-PC
GABPI-PD
NP_001285573.1
NP_001285574.1
NP_608741.1
NP_722869.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    3030539..3032300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298644.1 → NP_001285573.1  beta4GalNAcTB pilot, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285573.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2J6Q6
    Conserved Domains (1) summary
    pfam01529
    Location:185 → 322
    zf-DHHC; DHHC palmitoyltransferase

  2. NM_164522.3 → NP_722869.1  beta4GalNAcTB pilot, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_722869.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T0C4, Q9VQK9
    Related
    FBpp0077337
    Conserved Domains (1) summary
    pfam01529
    Location:262 → 399
    zf-DHHC; DHHC palmitoyltransferase

  3. NM_134897.5 → NP_608741.1  beta4GalNAcTB pilot, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608741.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T0C4, Q9VQK9
    Related
    FBpp0077336
    Conserved Domains (1) summary
    pfam01529
    Location:262 → 399
    zf-DHHC; DHHC palmitoyltransferase

  4. NM_001298645.1 → NP_001285574.1  beta4GalNAcTB pilot, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285574.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2J6Q6
    Conserved Domains (1) summary
    pfam01529
    Location:185 → 322
    zf-DHHC; DHHC palmitoyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VQK9 Q9VQK9
X2J6Q6 X2J6Q6

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