wasb WASP actin nucleation promoting factor b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: wasbprovided by ZNC
Official Full Name: WASP actin nucleation promoting factor bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-7098
See related: Ensembl:ENSDARG00000026350 AllianceGenome:ZFIN:ZDB-GENE-030131-7098
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: was; zgc:64164; wu:fk81c08
Summary: Predicted to enable small GTPase binding activity. Acts upstream of or within leukocyte chemotaxis; myoblast fusion; and regulation of neutrophil migration. Predicted to be located in cytoskeleton and nucleus. Predicted to be active in cytoplasm. Is expressed in hematopoietic system; leukocyte; neuromast; thrombocyte; and thymus. Used to study Wiskott-Aldrich syndrome. Human ortholog(s) of this gene implicated in Wiskott-Aldrich syndrome; X-linked severe congenital neutropenia; and thrombocytopenia. Orthologous to human WAS (WASP actin nucleation promoting factor). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (23560182..23578660, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (23538943..23557421, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The effects of morpholino knockdown of WASp1 (also known as Was) on leukocyte migration in response to a wound, was live-imaged in zebrafish larvae.
Title: Analysis of WASp function during the wound inflammatory response--live-imaging studies in zebrafish larvae.

Submit: New GeneRIF Correction

General gene information

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Markers

fj50f02.y1 (e-PCR)
- UniSTS:199473

fk81c08.x1 (e-PCR)
- UniSTS:201563

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin filament organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within leukocyte chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within macrophage chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within myoblast fusion	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within myoblast fusion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neutrophil chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin filament polymerization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of neutrophil migration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: WASP actin nucleation promoting factor b

Names: Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b; wasp1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199938.1 → NP_956232.1 WASP actin nucleation promoting factor b

See identical proteins and their annotated locations for NP_956232.1

Status: PROVISIONAL

Source sequence(s)

BC053291

UniProtKB/TrEMBL

Q7T318

Related

ENSDARP00000039217.4, ENSDART00000039080.6

Conserved Domains (2) summary

cd01205
Location:36 → 135

EVH1_WASP-like; WASP family proteins EVH1 domain

pfam00786
Location:220 → 276

PBD; P21-Rho-binding domain