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okr okra [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33507, updated on 9-Dec-2024

Summary

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Official Symbol
okrprovided by FlyBase
Official Full Name
okraprovided by FlyBase
Primary source
FLYBASE:FBgn0002989
Locus tag
Dmel_CG3736
See related
AllianceGenome:FB:FBgn0002989
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3736; DhR54; Dmel\CG3736; Dmrad54; DmRad54; DmRAD54; Okr; OKR; rad54; Rad54; RAD54; RAD54L; Ras54
Summary
Enables ATP hydrolysis activity and ATP-dependent chromatin remodeler activity. Involved in several processes, including DNA metabolic process; oocyte fate determination; and response to ionizing radiation. Located in nucleus. Is expressed in organism and ovary. Human ortholog(s) of this gene implicated in breast cancer; disease of cellular proliferation; non-Hodgkin lymphoma; and pancreatic cancer. Orthologous to human RAD54L (RAD54 like). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See okr in Genome Data Viewer
Location:
23C4-23C4; 2-8 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2989594..2992759, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2989594..2992759, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Chromodomain-helicase-DNA-binding protein 1 Neighboring gene Bem46 Neighboring gene uncharacterized protein Neighboring gene Ccdc85

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genomic integrity and the repair of double-strand DNA breaks. Pastink A, et al. Mutat Res, 2001 Sep 1. PMID 11506797
  2. The Drosophila melanogaster RAD54 homolog, DmRAD54, is involved in the repair of radiation damage and recombination. Kooistra R, et al. Mol Cell Biol, 1997 Oct. PMID 9315669, Free PMC Article
  3. The Drosophila melanogaster DNA Ligase IV gene plays a crucial role in the repair of radiation-induced DNA double-strand breaks and acts synergistically with Rad54. Gorski MM, et al. Genetics, 2003 Dec. PMID 14704177, Free PMC Article
  4. The development of a monoclonal antibody recognizing the Drosophila melanogaster phosphorylated histone H2A variant (γ-H2AV). Lake CM, et al. G3 (Bethesda), 2013 Sep 4. PMID 23833215, Free PMC Article
  5. Lig4 and rad54 are required for repair of DNA double-strand breaks induced by P-element excision in Drosophila. Romeijn RJ, et al. Genetics, 2005 Feb. PMID 15545651, Free PMC Article

See all (119) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that the frequency of HR dropped significantly in flies homozygous for mutations in spnA (Rad51) or okr (Rad54).
    Title: Genetic analysis of zinc-finger nuclease-induced gene targeting in Drosophila.
  2. RAD54 is required for repair of DNA double-strand breaks induced by P-element excision.
    Title: Lig4 and rad54 are required for repair of DNA double-strand breaks induced by P-element excision in Drosophila.
  3. A conserved N-terminal motif in Rad54 is important for chromatin remodeling and homologous strand pairing. Its autoinhibitory activity is relieved by Rad51.
    Title: A conserved N-terminal motif in Rad54 is important for chromatin remodeling and homologous strand pairing.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP-dependent chromatin remodeler activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP-dependent chromatin remodeler activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA translocase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA synthesis involved in double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dorsal appendage formation HMP PubMed 
involved_in double-strand break repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair via synthesis-dependent strand annealing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via synthesis-dependent strand annealing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular mRNA localization TAS
Traceable Author Statement
more info
 PubMed 
involved_in meiotic DNA repair synthesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oocyte fate determination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oogenesis HMP PubMed 
involved_in oogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in reciprocal meiotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of translation TAS
Traceable Author Statement
more info
 PubMed 
involved_in response to ionizing radiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
okra
Names
CG3736-PA
okr-PA
NP_476661.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    2989594..2992759 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057313.5 → NP_476661.1  okra [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476661.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B6UXG7, B6UXH8, B6UXJ2, B6UXJ5, O76460, P91636, Q7K0T1, Q7KPH9
    Related
    FBpp0077357
    Conserved Domains (3) summary
    cd00046
    Location:179 → 328
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00079
    Location:493 → 622
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam00176
    Location:159 → 466
    SNF2_N; SNF2 family N-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O76460.1 O76460

Gene LinkOut

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Chemical Information
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