lilli lilliputian [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: lilliprovided by FlyBase
Official Full Name: lilliputianprovided by FlyBase
Primary source: FLYBASE:FBgn0041111
Locus tag: Dmel_CG8817
See related: AllianceGenome:FB:FBgn0041111
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 154454_at; 189Y; AFF4; BcDNA:GM02019; BEST:GH09955; CG8817; dAFF; dAFF4; Dmel\CG8817; l(2)00632; l(2)23Cc; l(2)K00632; l(2)k07920; l(2)K07920; l(2)k16124; Lilli; S(ls)4; SS2-1; Su(Raf)2a; Su(Raf)2A; SY2-1
Summary: Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and transcription coregulator activity. Involved in several processes, including neuronal stem cell population maintenance; positive regulation of transcription by RNA polymerase II; and regionalization. Located in euchromatin and nucleus. Part of super elongation complex. Is expressed in several structures, including brain; large field neurons; nerve; presumptive embryonic/larval system; and synaptic neuropil domain. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in KINSSHIP syndrome and X-linked intellectual developmental disorder 109. Orthologous to several human genes including AFF2 (ALF transcription elongation factor 2); AFF3 (ALF transcription elongation factor 3); and AFF4 (ALF transcription elongation factor 4). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 23C1-23C3; 2-8 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (2885929..2954406)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (2885929..2954406)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Examination of Niddm20 candidate genes of OLETF rats in Drosophila melanogaster using inducible GeneSwitch GAL4 system.
Title: Examination of Niddm20 candidate genes of OLETF rats in Drosophila melanogaster using inducible GeneSwitch GAL4 system.
Lilli regulates the transcription and toxicity of expanded G4C2 repeats by specifically downregulating the transcription of GC-rich sequences in Drosophila.
Title: Transcription elongation factor AFF2/FMR2 regulates expression of expanded GGGGCC repeat-containing C9ORF72 allele in ALS/FTD.
lilliputian is part of the genetic program that regulates the expression of proneural genes in the developing retina.
Title: Drosophila lilliputian is required for proneural gene expression in retinal development.
Lilli plays an architectural role in facilitating transcriptional activation that depends both on the target gene and the developmental context
Title: The HMG-box protein Lilliputian is required for Runt-dependent activation of the pair-rule gene fushi-tarazu.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0230 (e-PCR)
- UniSTS:43267

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coregulator activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in learning or memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuronal stem cell population maintenance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuronal stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in periodic partitioning by pair rule gene	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in regulation of lipid transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in segment specification	HMP more info	PubMed
involved_in wing disc dorsal/ventral pattern formation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in euchromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of super elongation complex	IBA Inferred from Biological aspect of Ancestor more info
part_of super elongation complex	IPI Inferred from Physical Interaction more info	PubMed
part_of transcription elongation factor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: lilliputian

Names: CG8817-PA; CG8817-PB; CG8817-PC; CG8817-PD; CG8817-PE; CG8817-PF; CG8817-PG; CG8817-PH; CG8817-PI; liliputian; lilli-PA; lilli-PB; lilli-PC; lilli-PD; lilli-PE; lilli-PF; lilli-PG; lilli-PH; lilli-PI; suppressor of GMR-sina 2-1