larp7 La ribonucleoprotein 7, transcriptional regulator [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: larp7provided by ZNC
Official Full Name: La ribonucleoprotein 7, transcriptional regulatorprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-6896
See related: Ensembl:ENSDARG00000017315 AllianceGenome:ZFIN:ZDB-GENE-030131-6896
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fa10g04; zgc:56476; wu:fa10g04
Summary: Predicted to enable 7SK snRNA binding activity; U6 snRNA binding activity; and mRNA binding activity. Acts upstream of or within cardiac muscle tissue regeneration and regulation of cardiac muscle cell proliferation. Predicted to be located in nucleoplasm. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleus. Is expressed in blastoderm cell and brain. Orthologous to human LARP7 (La ribonucleoprotein 7, transcriptional regulator). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (59575819..59589622, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (59270509..59284422, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The balance of Cdk9 and Larp7 plays a key role in cardiomyocyte proliferation and response to injury
Title: CDK9 and its repressor LARP7 modulate cardiomyocyte proliferation and response to injury in the zebrafish heart.

Submit: New GeneRIF Correction

General gene information

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Markers

fa10g04.s1 (e-PCR)
- UniSTS:188803

aa495491 (e-PCR)
- UniSTS:186863

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 7SK snRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables U6 snRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in U6 2'-O-snRNA methylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in box C/D sno(s)RNA 3'-end processing	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cardiac muscle tissue regeneration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein localization to Cajal body	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of snRNA transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of cardiac muscle cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within spermatogenesis	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: la-related protein 7

Names: HDCMA18P protein; La ribonucleoprotein domain family, member 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199930.2 → NP_956224.1 la-related protein 7

See identical proteins and their annotated locations for NP_956224.1

Status: PROVISIONAL

Source sequence(s)

BC049455

UniProtKB/Swiss-Prot

Q7ZWE3

Related

ENSDARP00000013520.4, ENSDART00000008554.5

Conserved Domains (3) summary

cd12290
Location:134 → 212

RRM1_LARP7; RNA recognition motif 1 in La-related protein 7 (LARP7) and similar proteins

pfam08777
Location:429 → 527

RRM_3; RNA binding motif

cl02755
Location:38 → 119

LAM; LA motif RNA-binding domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007118.7 Reference GRCz11 Primary Assembly

Range

59575819..59589622 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005166534.5 → XP_005166591.1 la-related protein 7 isoform X1

UniProtKB/TrEMBL

A0A8M2BE41, E7F7F2

Related

ENSDARP00000092507.3, ENSDART00000101731.5

Conserved Domains (3) summary

cd08032
Location:38 → 119

LARP_7; La RNA-binding domain of La-related protein 7

cd12290
Location:134 → 212

RRM1_LARP7; RNA recognition motif 1 in La-related protein 7 (LARP7) and similar proteins

pfam08777
Location:429 → 527

RRM_3; RNA binding motif