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CG8814 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33492, updated on 4-Jan-2025

Summary

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Official Symbol
CG8814provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0031478
Locus tag
Dmel_CG8814
See related
AllianceGenome:FB:FBgn0031478
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
DmCG8814; Dmel\CG8814
Summary
Predicted to enable fatty-acyl-CoA binding activity. Predicted to be involved in fatty acid metabolic process. Predicted to be active in cytoplasm. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in retinal dystrophy with leukodystrophy. Orthologous to several human genes including ACBD5 (acyl-CoA binding domain containing 5). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG8814 in Genome Data Viewer
Location:
23B8-23C1; 2-8 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2874890..2877168)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2874890..2877168)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Interferon-related developmental regulator 1 Neighboring gene uncharacterized protein Neighboring gene Peroxiredoxin 6a Neighboring gene Rab geranylgeranyltransferase subunit beta Neighboring gene Sabbat Neighboring gene NTPase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. New insights into the functions of ACBD4/5-like proteins using a combined phylogenetic and experimental approach across model organisms. Kors S, et al. Biochim Biophys Acta Mol Cell Res, 2024 Dec. PMID 39271061
  2. The ACBP gene family in Rhodnius prolixus: Expression, characterization and function of RpACBP-1. Majerowicz D, et al. Insect Biochem Mol Biol, 2016 May. PMID 27001070
  3. Monitoring lipid alterations in Drosophila heads in an amyotrophic lateral sclerosis model with time-of-flight secondary ion mass spectrometry. Le MUT, et al. Analyst, 2024 Jan 29. PMID 38167886
  4. Genetic architecture of natural variation in cuticular hydrocarbon composition in Drosophila melanogaster. Dembeck LM, et al. Elife, 2015 Nov 14. PMID 26568309, Free PMC Article
  5. EMC is required for biogenesis of Xport-A, an essential chaperone of Rhodopsin-1 and the TRP channel. Gaspar CJ, et al. EMBO Rep, 2022 Jan 5. PMID 34918864, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables fatty-acyl-CoA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fatty-acyl-CoA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG8814-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    2874890..2877168
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_134885.4 → NP_608729.1  uncharacterized protein Dmel_CG8814 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608729.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VQI6
    Related
    FBpp0077314
    Conserved Domains (2) summary
    pfam00887
    Location:5 → 90
    ACBP; Acyl CoA binding protein
    pfam07889
    Location:217 → 272
    DUF1664; Protein of unknown function (DUF1664)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VQI6 Q9VQI6

Gene LinkOut

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