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RpS21 Ribosomal protein S21 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33487, updated on 9-Dec-2024

Summary

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Official Symbol
RpS21provided by FlyBase
Official Full Name
Ribosomal protein S21provided by FlyBase
Primary source
FLYBASE:FBgn0015521
Locus tag
Dmel_CG2986
See related
AllianceGenome:FB:FBgn0015521
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2986; Dmel\CG2986; l(2)03575; l(2)168/14; l(2)k16814; M(2)23B; oho23; oho23B; rpS21; S21; S21e
Summary
Enables ribosome binding activity. A structural constituent of ribosome. Involved in lymph gland development and regulation of cell population proliferation. Located in cytosolic ribosome. Is expressed in adult heart; imaginal disc; and organism. Orthologous to human RPS21 (ribosomal protein S21). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See RpS21 in Genome Data Viewer
Location:
23B5-23B6; 2-7 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2856070..2857029)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2856070..2857029)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Interferon-related developmental regulator 1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Down-regulation of RpS21, a putative translation initiation factor interacting with P40, produces viable minute imagos and larval lethality with overgrown hematopoietic organs and imaginal discs. Török I, et al. Mol Cell Biol, 1999 Mar. PMID 10022917, Free PMC Article
  2. Allele-specific alternative splicing of Drosophila Ribosomal protein S21 suppresses a lethal mutation in the Phosphorylated adaptor for RNA export (Phax) gene. Garcia EL. G3 (Bethesda), 2022 Aug 25. PMID 35920767, Free PMC Article
  3. An RNAi screen for ribosome biogenesis genes required for Drosophila border cell collective migration. Burghardt E, et al. MicroPubl Biol, 2024. PMID 39185014, Free PMC Article
  4. Exploiting codon usage identifies intensity-specific modifiers of Ras/MAPK signaling in vivo. Sawyer JK, et al. PLoS Genet, 2020 Dec. PMID 33296356, Free PMC Article
  5. Opbp is a new architectural/insulator protein required for ribosomal gene expression. Zolotarev N, et al. Nucleic Acids Res, 2017 Dec 1. PMID 29036346, Free PMC Article

See all (73) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ribosome binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of ribosome HDA PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of ribosome TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic translation IC
Inferred by Curator
more info
 PubMed 
involved_in cytoplasmic translation TAS
Traceable Author Statement
more info
 PubMed 
involved_in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lymph gland development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosolic ribosome HDA PubMed 
located_in cytosolic ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic small ribosomal subunit TAS
Traceable Author Statement
more info
 PubMed 
located_in ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ribosomal protein S21
Names
CG2986-PA
CG2986-PB
CG2986-PD
CG2986-PE
CG2986-PF
Rp S21
RpS21-PA
RpS21-PB
RpS21-PD
RpS21-PE
RpS21-PF
overgrown hematopoietic organs 23B
overgrown hematopoietic organs at 23B
overgrown hematopoietic organs-23

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    2856070..2857029
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078738.5 → NP_523462.2  ribosomal protein S21, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523462.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    E4NKJ9
    Conserved Domains (1) summary
    pfam01249
    Location:1 → 77
    Ribosomal_S21e; Ribosomal protein S21e

  2. NM_001273041.1 → NP_001259970.1  ribosomal protein S21, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259970.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V027, O76927
    UniProtKB/TrEMBL
    E4NKJ9, M9PEA6
    Conserved Domains (1) summary
    pfam01249
    Location:1 → 79
    Ribosomal_S21e; Ribosomal protein S21e

  3. NM_164507.4 → NP_722854.1  ribosomal protein S21, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_722854.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V027, O76927
    UniProtKB/TrEMBL
    E4NKJ9, M9PEA6
    Related
    FBpp0077309
    Conserved Domains (1) summary
    pfam01249
    Location:1 → 79
    Ribosomal_S21e; Ribosomal protein S21e

  4. NM_164508.3 → NP_722855.1  ribosomal protein S21, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_722855.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V027, O76927
    UniProtKB/TrEMBL
    E4NKJ9, M9PEA6
    Related
    FBpp0077308
    Conserved Domains (1) summary
    pfam01249
    Location:1 → 79
    Ribosomal_S21e; Ribosomal protein S21e

  5. NM_164506.4 → NP_722853.1  ribosomal protein S21, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_722853.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V027, O76927
    UniProtKB/TrEMBL
    E4NKJ9, M9PEA6
    Related
    FBpp0077307
    Conserved Domains (1) summary
    pfam01249
    Location:1 → 79
    Ribosomal_S21e; Ribosomal protein S21e
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PEA6 M9PEA6
O76927.1 O76927

Gene LinkOut

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