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G6P Glucose-6-Phosphatase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33476, updated on 4-Jan-2025

Summary

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Official Symbol
G6Pprovided by FlyBase
Official Full Name
Glucose-6-Phosphataseprovided by FlyBase
Primary source
FLYBASE:FBgn0031463
Locus tag
Dmel_CG15400
See related
AllianceGenome:FB:FBgn0031463
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG15400; Dmel\CG15400; G6pase; G6Pase; G6PC
Summary
Predicted to enable glucose-6-phosphatase activity. Involved in gluconeogenesis. Predicted to be located in endoplasmic reticulum. Predicted to be active in membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in glycogen storage disease Ia; hepatocellular carcinoma; severe congenital neutropenia 4; and type 2 diabetes mellitus. Orthologous to several human genes including G6PC1 (glucose-6-phosphatase catalytic subunit 1) and G6PC2 (glucose-6-phosphatase catalytic subunit 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See G6P in Genome Data Viewer
Location:
23B2-23B2; 2-7 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2814336..2815760, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2814336..2815760, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Synaptotagmin 1 Neighboring gene long non-coding RNA:CR43821 Neighboring gene dawdle Neighboring gene uncharacterized protein Neighboring gene Dual oxidase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Gluconeogenesis: An ancient biochemical pathway with a new twist. Miyamoto T, et al. Fly (Austin), 2017 Jul 3. PMID 28121487, Free PMC Article
  2. Drosophila neuronal Glucose-6-Phosphatase is a modulator of neuropeptide release that regulates muscle glycogen stores via FMRFamide signaling. Miyamoto T, et al. Proc Natl Acad Sci U S A, 2024 Jul 23. PMID 39008673, Free PMC Article
  3. Organically grown food provides health benefits to Drosophila melanogaster. Chhabra R, et al. PLoS One, 2013. PMID 23326371, Free PMC Article
  4. Neuronal Gluconeogenesis Regulates Systemic Glucose Homeostasis in Drosophila melanogaster. Miyamoto T, et al. Curr Biol, 2019 Apr 22. PMID 30930040
  5. Reduced branched-chain aminotransferase activity alleviates metabolic vulnerability caused by dim light exposure at night in Drosophila. Kim M, et al. J Neurogenet, 2023 Mar-Dec. PMID 36415929

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Drosophila neuronal Glucose-6-Phosphatase is a modulator of neuropeptide release that regulates muscle glycogen stores via FMRFamide signaling.
    Title: Drosophila neuronal Glucose-6-Phosphatase is a modulator of neuropeptide release that regulates muscle glycogen stores via FMRFamide signaling.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables glucose-6-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucose-6-phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in gluconeogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glucose 6-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Glucose-6-Phosphatase
Names
CG15400-PB
G6P-PB
glucose-6-phosphatase alpha
NP_001097063.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    2814336..2815760 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001103593.2 → NP_001097063.1  Glucose-6-Phosphatase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097063.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VQH1
    Conserved Domains (1) summary
    cd03381
    Location:49 → 290
    PAP2_glucose_6_phosphatase; PAP2_like proteins, glucose-6-phosphatase subfamily. Glucose-6-phosphatase converts glucose-6-phosphate into free glucose and is active in the lumen of the endoplasmic reticulum, where it is bound to the membrane. The generation of free glucose is an ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VQH1 Q9VQH1

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