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strada STE20 related adaptor alpha [ Danio rerio (zebrafish) ]

Gene ID: 334550, updated on 4-Jan-2025

Summary

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Official Symbol
stradaprovided by ZNC
Official Full Name
STE20 related adaptor alphaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-6482
See related
Ensembl:ENSDARG00000037929 AllianceGenome:ZFIN:ZDB-GENE-030131-6482
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fj99g05; zgc:56109; wu:fj99g05
Summary
Predicted to enable ATP binding activity; protein kinase activity; and protein serine/threonine kinase activator activity. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in cytoplasm and nucleus. Is expressed in testis. Used to study epilepsy. Human ortholog(s) of this gene implicated in polyhydramnios, megalencephaly, and symptomatic epilepsy. Orthologous to human STRADA (STE20 related adaptor alpha). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See strada in Genome Data Viewer
Location:
chromosome: 3
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (31897029..31922259)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (31765238..31785676)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene zona pellucida glycoprotein 3e Neighboring gene DEAD (Asp-Glu-Ala-Asp) box helicase 42 Neighboring gene ring finger protein 113A Neighboring gene small nuclear ribonucleoprotein 70 (U1) Neighboring gene uncharacterized LOC110439178 Neighboring gene lin-7 homolog B (C. elegans)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Phenotypic analysis of catastrophic childhood epilepsy genes. Griffin A, et al. Commun Biol, 2021 Jun 3. PMID 34083748, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
STE20-related kinase adapter protein alpha
Names
ste20-related kinase adaptor alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199911.2 → NP_956205.2  STE20-related kinase adapter protein alpha

    See identical proteins and their annotated locations for NP_956205.2

    Status: VALIDATED

    Source sequence(s)
    BX324157
    UniProtKB/TrEMBL
    A0A8M1PC44, F1Q5T1
    Related
    ENSDARP00000115217.1, ENSDART00000146275.3
    Conserved Domains (2) summary
    smart00220
    Location:11 → 325
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:12 → 342
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    31897029..31922259
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068215947.1 → XP_068072048.1  STE20-related kinase adapter protein alpha isoform X2

    UniProtKB/TrEMBL
    A0A8M1PC44, F1Q5T1

  2. XM_021469637.2 → XP_021325312.1  STE20-related kinase adapter protein alpha isoform X1

    UniProtKB/TrEMBL
    A0A8M9P4U0
    Conserved Domains (1) summary
    cl21453
    Location:76 → 406
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version

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