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Prosbeta4R1 Proteasome beta4 subunit-related 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33449, updated on 9-Dec-2024

Summary

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Official Symbol
Prosbeta4R1provided by FlyBase
Official Full Name
Proteasome beta4 subunit-related 1provided by FlyBase
Primary source
FLYBASE:FBgn0031442
Locus tag
Dmel_CG17301
See related
AllianceGenome:FB:FBgn0031442
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:AT30033; beta4R1; CG17301; Dmel\CG17301
Summary
Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of proteasome core complex, beta-subunit complex. Predicted to be active in cytosol and nucleus. Orthologous to human PSMB2 (proteasome 20S subunit beta 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Prosbeta4R1 in Genome Data Viewer
Location:
23A2-23A2; 2-7 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2653046..2653926)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2653046..2653926)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Proteasome beta4 subunit-related 2 Neighboring gene Odorant receptor 23a Neighboring gene TBP-related factor 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Proteasome Structure and Assembly. Budenholzer L, et al. J Mol Biol, 2017 Nov 10. PMID 28583440, Free PMC Article
  2. Population genomic inferences from sparse high-throughput sequencing of two populations of Drosophila melanogaster. Sackton TB, et al. Genome Biol Evol, 2009 Nov 18. PMID 20333214, Free PMC Article
  3. Expression of proteasome subunit isoforms during spermatogenesis in Drosophila melanogaster. Ma J, et al. Insect Mol Biol, 2002 Dec. PMID 12421421
  4. Lethality in Drosophila melanogaster/Drosophila simulans species hybrids is not associated with substantial transcriptional misregulation. Barbash DA, et al. J Exp Zool B Mol Dev Evol, 2007 Jan 15. PMID 17075830
  5. Duplicated proteasome subunit genes in Drosophila and their roles in spermatogenesis. Belote JM, et al. Heredity (Edinb), 2009 Jul. PMID 19277057

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
NOT enables peptidase activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteasomal protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome core complex IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome core complex, beta-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome core complex, beta-subunit complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
proteasome beta4 subunit-related 1
Names
CG17301-PA
Prosbeta4R1-PA
proteasome beta4R1 subunit

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    2653046..2653926
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_134854.3 → NP_608698.2  proteasome beta4 subunit-related 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608698.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T8U1, Q9VQE4
    Related
    FBpp0077381
    Conserved Domains (2) summary
    COG0638
    Location:1 → 204
    PRE1; 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]
    cd03758
    Location:1 → 193
    proteasome_beta_type_2; proteasome beta type-2 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8T8U1 Q8T8U1

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