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Rad1 Radiation insensitive 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33440, updated on 9-Dec-2024

Summary

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Official Symbol
Rad1provided by FlyBase
Official Full Name
Radiation insensitive 1provided by FlyBase
Primary source
FLYBASE:FBgn0026778
Locus tag
Dmel_CG3240
See related
AllianceGenome:FB:FBgn0026778
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3240; Dmel\CG3240; DmRad1; Dromel_CG3240_FBtr0077747_rad1_mORF; rad1; Rad1[Dm]
Summary
Predicted to be involved in DNA damage checkpoint signaling and DNA repair. Part of checkpoint clamp complex. Is expressed in ovary. Orthologous to human RAD1 (RAD1 checkpoint DNA exonuclease). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Rad1 in Genome Data Viewer
Location:
23A1-23A1; 2-7 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2573436..2575052, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2573436..2575052, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Cytochrome P450 309a1 Neighboring gene Cytochrome P450 309a2 Neighboring gene SWIM domain containing Srs2 interacting protein 1 Neighboring gene insensitive Neighboring gene Early boundary activity 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Localization of the Drosophila Rad9 protein to the nuclear membrane is regulated by the C-terminal region and is affected in the meiotic checkpoint. Kadir R, et al. PLoS One, 2012. PMID 22666434, Free PMC Article
  2. p53 and cyclin G cooperate in mediating genome stability in somatic cells of Drosophila. Bayer FE, et al. Sci Rep, 2017 Dec 20. PMID 29263364, Free PMC Article
  3. An essential role for Drosophila hus1 in somatic and meiotic DNA damage responses. Abdu U, et al. J Cell Sci, 2007 Mar 15. PMID 17327271, Free PMC Article
  4. Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Ashburner M, et al. Nat Genet, 2000 May. PMID 10802651, Free PMC Article
  5. The Atr-Chek1 pathway inhibits axon regeneration in response to Piezo-dependent mechanosensation. Li F, et al. Nat Commun, 2021 Jun 22. PMID 34158506, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA damage checkpoint signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of checkpoint clamp complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of checkpoint clamp complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
radiation insensitive 1
Names
CG3240-PA
Rad1-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    2573436..2575052 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058092.4 → NP_477440.1  radiation insensitive 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477440.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VQD4, Q9XYT3
    Related
    FBpp0077427
    Conserved Domains (2) summary
    cd00577
    Location:13 → 272
    PCNA; Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the ...
    pfam02144
    Location:13 → 253
    Rad1; Repair protein Rad1/Rec1/Rad17
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VQD4 Q9VQD4

Gene LinkOut

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