zmpste24 zinc metallopeptidase, STE24 homolog [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: zmpste24provided by ZNC
Official Full Name: zinc metallopeptidase, STE24 homologprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-6312
See related: Ensembl:ENSDARG00000044090 AllianceGenome:ZFIN:ZDB-GENE-030131-6312
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fi45a02; zgc:55655; wu:fi45a02
Summary: Predicted to enable metalloendopeptidase activity. Predicted to be involved in CAAX-box protein processing. Predicted to act upstream of or within proteolysis. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in mandibuloacral dysplasia type B lipodystrophy; restrictive dermopathy; and restrictive dermopathy 1. Orthologous to human ZMPSTE24 (zinc metallopeptidase STE24). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (24604404..24612296)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (24586003..24593895)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fi45a02.x1 (e-PCR)
- UniSTS:197553

fe06h01.y1 (e-PCR)
- UniSTS:196039

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in CAAX-box protein processing	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within CAAX-box protein processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: CAAX prenyl protease 1 homolog

Names: zinc metalloproteinase (STE24 homolog, yeast)

NP_956186.1

EC 3.4.24.84

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199892.1 → NP_956186.1 CAAX prenyl protease 1 homolog

See identical proteins and their annotated locations for NP_956186.1

Status: PROVISIONAL

Source sequence(s)

BC046884

UniProtKB/TrEMBL

Q802Z1

Related

ENSDARP00000076630.3, ENSDART00000082193.4

Conserved Domains (3) summary

COG0501
Location:176 → 463

HtpX; Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]

pfam01435
Location:223 → 465

Peptidase_M48; Peptidase family M48

pfam16491
Location:36 → 220

Peptidase_M48_N; CAAX prenyl protease N-terminal, five membrane helices