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zranb1a zinc finger, RAN-binding domain containing 1a [ Danio rerio (zebrafish) ]

Gene ID: 334230, updated on 9-Dec-2024

Summary

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Official Symbol
zranb1aprovided by ZNC
Official Full Name
zinc finger, RAN-binding domain containing 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-100212-3
See related
Ensembl:ENSDARG00000060257 AllianceGenome:ZFIN:ZDB-GENE-100212-3
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fi37b03; wu:fi37b03
Summary
Predicted to enable cysteine-type deubiquitinase activity and metal ion binding activity. Acts upstream of or within brain development. Is expressed in female organism. Orthologous to human ZRANB1 (zinc finger RANBP2-type containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See zranb1a in Genome Data Viewer
Location:
chromosome: 12
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (47044787..47072244)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (47104471..47125421)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene phospholysine phosphohistidine inorganic pyrophosphate phosphatase Neighboring gene ornithine aminotransferase Neighboring gene 5-methyltetrahydrofolate-homocysteine methyltransferase Neighboring gene ryanodine receptor 2a (cardiac)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Large-scale discovery of novel genetic causes of developmental disorders. Deciphering Developmental Disorders Study. Nature, 2015 Mar 12. PMID 25533962, Free PMC Article
  2. Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development. Tse WK, et al. BMC Genomics, 2009 Dec 30. PMID 20040115, Free PMC Article
  3. Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Newman M, et al. Mol Brain, 2019 May 3. PMID 31053140, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within brain development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
LOW QUALITY PROTEIN: ubiquitin thioesterase ZRANB1; zinc finger, RAN-binding domain containing 1a
XP_009305260.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    47044787..47072244
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009306985.4 → XP_009305260.1  LOW QUALITY PROTEIN: ubiquitin thioesterase ZRANB1

    UniProtKB/TrEMBL
    A0A8M3BED9
    Related
    ENSDARP00000079149.6, ENSDART00000084714.6
    Conserved Domains (3) summary
    smart00547
    Location:7 → 29
    ZnF_RBZ; Zinc finger domain
    sd00029
    Location:8 → 27
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam02338
    Location:419 → 567
    OTU; OTU-like cysteine protease
Nucleotide Protein Strain
Heading Accession and Version

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Molecular Biology Databases
Research Materials