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Send1 Spermathecal endopeptidase 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33407, updated on 4-Jan-2025

Summary

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Official Symbol
Send1provided by FlyBase
Official Full Name
Spermathecal endopeptidase 1provided by FlyBase
Primary source
FLYBASE:FBgn0031406
Locus tag
Dmel_CG17012
See related
AllianceGenome:FB:FBgn0031406
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG17012; Dmel\CG17012; SP163
Summary
Enables serine hydrolase activity. Predicted to be involved in proteolysis. Is expressed in female accessory gland; seminal receptacle; and spermatheca. Orthologous to human PRSS36 (serine protease 36) and PRSS53 (serine protease 53). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Send1 in Genome Data Viewer
Location:
22D5-22D5; 2-5 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2254176..2255050, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2254176..2255050, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44787 Neighboring gene long non-coding RNA:CR44788

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sperm-storage defects and live birth in Drosophila females lacking spermathecal secretory cells. Schnakenberg SL, et al. PLoS Biol, 2011 Nov. PMID 22087073, Free PMC Article
  2. Drosophila female reproductive glands contribute to mating plug composition and the timing of sperm ejection. McDonough-Goldstein CE, et al. Proc Biol Sci, 2022 Feb 9. PMID 35105240, Free PMC Article
  3. Molecular evolution and population genetic analysis of candidate female reproductive genes in Drosophila. Panhuis TM, et al. Genetics, 2006 Aug. PMID 16783023, Free PMC Article
  4. Protease gene duplication and proteolytic activity in Drosophila female reproductive tracts. Kelleher ES, et al. Mol Biol Evol, 2009 Sep. PMID 19546158, Free PMC Article
  5. Molecular population genetics of female-expressed mating-induced serine proteases in Drosophila melanogaster. Lawniczak MK, et al. Mol Biol Evol, 2007 Sep. PMID 17573377

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A female reproductive tract expressed serine protease, GenBank Accession Number AM765858, that show increased transcription shortly after mating.
    Title: Molecular population genetics of female-expressed mating-induced serine proteases in Drosophila melanogaster.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables serine hydrolase activity HDA PubMed 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
spermathecal endopeptidase 1
Names
CG17012-PA
Send1-PA
NP_608662.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    2254176..2255050 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_134818.3 → NP_608662.1  spermathecal endopeptidase 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608662.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0GST5, Q9VQA0
    Related
    FBpp0077481
    Conserved Domains (2) summary
    smart00020
    Location:29 → 239
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:30 → 239
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VQA0 Q9VQA0

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