lrpap1 low density lipoprotein receptor-related protein associated protein 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lrpap1provided by ZNC
Official Full Name: low density lipoprotein receptor-related protein associated protein 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-5871
See related: Ensembl:ENSDARG00000033604 AllianceGenome:ZFIN:ZDB-GENE-030131-5871
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fi20f07; wu:fi22c06
Summary: Predicted to enable lipase binding activity; lipoprotein particle receptor binding activity; and receptor antagonist activity. Predicted to be involved in negative regulation of receptor internalization and negative regulation of very-low-density lipoprotein particle clearance. Predicted to be located in endoplasmic reticulum. Predicted to be active in several cellular components, including cis-Golgi network; endoplasmic reticulum-Golgi intermediate compartment; and rough endoplasmic reticulum lumen. Is expressed in head; neural tube; pronephros; and sensory system. Used to study myopia. Human ortholog(s) of this gene implicated in Alzheimer's disease; dementia; myocardial infarction; and myopia. Orthologous to human LRPAP1 (LDL receptor related protein associated protein 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (41131526..41141443)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (40428739..40438656)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lrpap1 deficiency leads to myopia through TGF-beta-induced apoptosis in zebrafish.
Title: Lrpap1 deficiency leads to myopia through TGF-β-induced apoptosis in zebrafish.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

lrpap1 (e-PCR), detects polymorphism
- UniSTS:205573

fi20f07.x1 (e-PCR)
- UniSTS:204498

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables lipase binding	IBA Inferred from Biological aspect of Ancestor more info
enables low-density lipoprotein particle receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables low-density lipoprotein particle receptor binding	IEA Inferred from Electronic Annotation more info
enables receptor antagonist activity	IBA Inferred from Biological aspect of Ancestor more info
enables receptor antagonist activity	IEA Inferred from Electronic Annotation more info
enables very-low-density lipoprotein particle receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of receptor internalization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of very-low-density lipoprotein particle clearance	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cis-Golgi network	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum-Golgi intermediate compartment	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in rough endoplasmic reticulum lumen	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: alpha-2-macroglobulin receptor-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201306.2 → NP_958463.2 alpha-2-macroglobulin receptor-associated protein precursor

Status: VALIDATED

Source sequence(s)

BX511116

UniProtKB/TrEMBL

Q7ZW96

Related

ENSDARP00000115274.1, ENSDART00000145272.2