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aop - anterior open

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein domain specific binding activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; negative regulation of cell differentiation; and regulation of gene expression. Located in cytosol and nucleus. Is expressed in several structures, including embryonic gnathal segment; germ layer; imaginal disc; larval optic anlage; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in hematologic cancer (multiple) and thrombocytopenia. Orthologous to human ETV6 (ETS variant transcription factor 6) and ETV7 (ETS variant transcription factor 7). [provided by Alliance of Genome Resources, Nov 2024]

Genes similar to aop

NCBI Orthologs

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Species Gene Architecture aa