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CG4238 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33377, updated on 9-Dec-2024

Summary

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Official Symbol
CG4238provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0031384
Locus tag
Dmel_CG4238
See related
AllianceGenome:FB:FBgn0031384
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG4238
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in negative regulation of apoptotic process and ubiquitin-dependent protein catabolic process. Predicted to be active in cytosol. Is expressed in adult head. Orthologous to human AREL1 (apoptosis resistant E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG4238 in Genome Data Viewer
Location:
22B8-22C1; 2-3 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2009859..2030788)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2009859..2030788)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene transfer RNA:Glutamine-CTG 2-2 Neighboring gene transfer RNA:Glutamine-CTG 2-3 Neighboring gene transfer RNA:Glutamine-CTG 2-4 Neighboring gene transfer RNA:Glutamine-CTG 3-1 Neighboring gene transfer RNA:Glutamine-CTG 2-5 Neighboring gene snoRNA:Orphan C/D box 14 Neighboring gene transfer RNA:Glycine-GCC 1-2 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Coordinated repression and activation of two transcriptional programs stabilizes cell fate during myogenesis. Ciglar L, et al. Development, 2014 Jul. PMID 24961800, Free PMC Article
  2. PRE-mediated bypass of two Su(Hw) insulators targets PcG proteins to a downstream promoter. Comet I, et al. Dev Cell, 2006 Jul. PMID 16824958
  3. A screen for E3 ubiquitination ligases that genetically interact with the adaptor protein Cindr during Drosophila eye patterning. Ketosugbo KF, et al. PLoS One, 2017. PMID 29117266, Free PMC Article
  4. Using single-cell RNA sequencing to generate predictive cell-type-specific split-GAL4 reagents throughout development. Chen YD, et al. Proc Natl Acad Sci U S A, 2023 Aug 8. PMID 37523539, Free PMC Article
  5. Dynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq. Gan Q, et al. Cell Res, 2010 Jul. PMID 20440302, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG4238-PD
CG4238-PE
CG4238-PF
CG4238-PG
CG4238-PH
CG4238-PI
CG4238-PJ

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    2009859..2030788
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001103583.3 → NP_001097053.2  uncharacterized protein Dmel_CG4238, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097053.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DYT2, Q8MZA5
    Conserved Domains (6) summary
    smart00454
    Location:41 → 99
    SAM; Sterile alpha motif
    smart00119
    Location:633 → 965
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    smart00557
    Location:229 → 327
    IG_FLMN; Filamin-type immunoglobulin domains
    cd00078
    Location:606 → 966
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00630
    Location:229 → 327
    Filamin; Filamin/ABP280 repeat
    cl15755
    Location:44 → 73
    SAM_superfamily; SAM (Sterile alpha motif )

  2. NM_001272966.1 → NP_001259895.1  uncharacterized protein Dmel_CG4238, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259895.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PE16, Q8MZA5
    Conserved Domains (6) summary
    smart00454
    Location:41 → 99
    SAM; Sterile alpha motif
    smart00119
    Location:627 → 959
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    smart00557
    Location:229 → 327
    IG_FLMN; Filamin-type immunoglobulin domains
    cd00078
    Location:600 → 960
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00630
    Location:229 → 327
    Filamin; Filamin/ABP280 repeat
    cl15755
    Location:44 → 73
    SAM_superfamily; SAM (Sterile alpha motif )

  3. NM_001272965.1 → NP_001259894.1  uncharacterized protein Dmel_CG4238, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259894.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DYT3, Q8MZA5
    Conserved Domains (4) summary
    smart00119
    Location:593 → 925
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    smart00557
    Location:189 → 287
    IG_FLMN; Filamin-type immunoglobulin domains
    cd00078
    Location:566 → 926
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00630
    Location:189 → 287
    Filamin; Filamin/ABP280 repeat

  4. NM_001272968.1 → NP_001259897.1  uncharacterized protein Dmel_CG4238, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259897.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DYT3, Q8MZA5
    Conserved Domains (4) summary
    smart00119
    Location:593 → 925
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    smart00557
    Location:189 → 287
    IG_FLMN; Filamin-type immunoglobulin domains
    cd00078
    Location:566 → 926
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00630
    Location:189 → 287
    Filamin; Filamin/ABP280 repeat

  5. NM_001103582.2 → NP_001097052.2  uncharacterized protein Dmel_CG4238, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097052.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DYT3, Q8MZA5
    Conserved Domains (4) summary
    smart00119
    Location:593 → 925
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    smart00557
    Location:189 → 287
    IG_FLMN; Filamin-type immunoglobulin domains
    cd00078
    Location:566 → 926
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00630
    Location:189 → 287
    Filamin; Filamin/ABP280 repeat

  6. NM_001272967.1 → NP_001259896.1  uncharacterized protein Dmel_CG4238, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259896.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VQ67
    Conserved Domains (4) summary
    smart00119
    Location:642 → 974
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    smart00557
    Location:238 → 336
    IG_FLMN; Filamin-type immunoglobulin domains
    cd00078
    Location:615 → 975
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00630
    Location:238 → 336
    Filamin; Filamin/ABP280 repeat

  7. NM_134796.4 → NP_608640.2  uncharacterized protein Dmel_CG4238, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608640.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VQ67
    Conserved Domains (4) summary
    smart00119
    Location:642 → 974
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    smart00557
    Location:238 → 336
    IG_FLMN; Filamin-type immunoglobulin domains
    cd00078
    Location:615 → 975
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00630
    Location:238 → 336
    Filamin; Filamin/ABP280 repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8DYT2 A8DYT2
A8DYT3 A8DYT3
M9PE16 M9PE16
Q8MZA5 Q8MZA5
Q9VQ67 Q9VQ67

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