Got2 Glutamate oxaloacetate transaminase 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Got2provided by FlyBase
Official Full Name: Glutamate oxaloacetate transaminase 2provided by FlyBase
Primary source: FLYBASE:FBgn0001125
Locus tag: Dmel_CG4233
See related: AllianceGenome:FB:FBgn0001125
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 152801_at; CG4233; Dmel\CG4233; Got; Got 2; Got-2; got2
Summary: Enables L-aspartate:2-oxoglutarate aminotransferase activity. Involved in glutamate biosynthetic process and synapse assembly. Located in mitochondrion. Is expressed in several structures, including adult head; adult heart; embryonic/larval fat body; gastric caecum; and gut section. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 82. Orthologous to human GOT2 (glutamic-oxaloacetic transaminase 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 22B8-22B8; 2-3 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (1984512..1987758, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (1984512..1987758, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables L-aspartate:2-oxoglutarate aminotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-aspartate:2-oxoglutarate aminotransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables transaminase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 2-oxoglutarate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in amino acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in aspartate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in aspartate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in glutamate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glutamate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in malate-aspartate shuttle	ISS Inferred from Sequence or Structural Similarity more info
involved_in oxaloacetate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: glutamate oxaloacetate transaminase 2

Names: CG4233-PA; CG4233-PB; GLUTAMATE OXALOACETATE TRANSAMINASE 2; Got2-PA; Got2-PB; mitochondrial aspartate aminotransferase

NP_722744.1

EC 2.6.1.-

EC 2.6.1.1

NP_722745.1

EC 2.6.1.-

EC 2.6.1.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

1984512..1987758 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_164445.4 → NP_722744.1 glutamate oxaloacetate transaminase 2, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_722744.1

Status: REVIEWED

UniProtKB/TrEMBL

H5V866, Q9VQ61

Related

FBpp0077536

Conserved Domains (2) summary

pfam00155
Location:51 → 419

Aminotran_1_2; Aminotransferase class I and II

cl18945
Location:17 → 424

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
NM_164446.1 → NP_722745.1 glutamate oxaloacetate transaminase 2, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_722745.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8IPY3, Q8T0M9

Related

FBpp0077537, FBtr0077868

Conserved Domains (2) summary

pfam00155
Location:58 → 426

Aminotran_1_2; Aminotransferase class I and II

cl18945
Location:21 → 431

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...