ebi ebi [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ebiprovided by FlyBase
Official Full Name: ebiprovided by FlyBase
Primary source: FLYBASE:FBgn0263933
Locus tag: Dmel_CG4063
See related: AllianceGenome:FB:FBgn0263933
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG4063; Dmel\CG4063; E-2f; E-2g; Ebi; FBXW4; l(2)k16213; Tb11; Tbl1
Summary: Enables DNA-binding transcription factor binding activity and chromatin binding activity. Involved in several processes, including imaginal disc-derived wing margin morphogenesis; positive regulation of imaginal disc growth; and regulation of signal transduction. Located in nucleus and polytene chromosome. Part of transcription repressor complex. Is expressed in several structures, including anterior endoderm; eye disc; ganglia; germline cell; and larval muscle system. Used to study sensory system disease. Human ortholog(s) of this gene implicated in Pierpont syndrome; Y-linked deafness 2; autosomal dominant intellectual developmental disorder 41; and congenital nongoitrous hypothyroidism 8. Orthologous to human TBL1XR1 (TBL1X/Y related 1); TBL1X (transducin beta like 1 X-linked); and TBL1Y (transducin beta like 1 Y-linked). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 21C2-21C2; 2-0.7 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (415067..418536)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (415067..418536)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study proposes that the interplay of Crb expression in the DV boundary and ubiquitin-dependent Crb downregulation by Ebi provides a mechanism for the maintenance of Notch signaling during wing development.
Title: Ebi modulates wing growth by ubiquitin-dependent downregulation of Crumbs in Drosophila.
Results offer clear in vivo evidence that the Ebi-containing co-repressor complex acts in a distinct manner to regulate transcription that is required for modulating the output of various processes during Drosophila development.
Title: Cellular Defense and Sensory Cell Survival Require Distinct Functions of ebi in Drosophila.
The antagonistic function of ebi against the Polycomb group silencing complex plays a role in the G1/S phase transition.
Title: Ebi alleviates excessive growth signaling through multiple epigenetic functions in Drosophila.
EBI acts to activate (de-repress) transcription of Notch target genes important for Drosophila wing growth by functioning as a corepressor/coactivator exchange factor for SU(H).
Title: Genetic characterization of ebi reveals its critical role in Drosophila wing growth.
Ebi/AP-1 suppresses basal transcription levels of apoptotic genes and thereby protects sensory neurons from degeneration
Title: Ebi/AP-1 suppresses pro-apoptotic genes expression and permits long-term survival of Drosophila sensory neurons.
Ebi directly interacts with the Snail repressor and regulates Snail repressor function in the early embryo and in tissue culture cells.
Title: Drosophila Ebi mediates Snail-dependent transcriptional repression through HDAC3-induced histone deacetylation.
An EGFR/Ebi/Sno pathway promotes delta expression by inactivating Su(H)/SMRTER repression during inductive notch signaling.
Title: An EGFR/Ebi/Sno pathway promotes delta expression by inactivating Su(H)/SMRTER repression during inductive notch signaling.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0349 (e-PCR)
- UniSTS:12585

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to light stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chaeta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in imaginal disc-derived wing margin morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of JNK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron cellular homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in photoreceptor cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Notch signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of Notch signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of imaginal disc growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of imaginal disc growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of epidermal growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in wing disc development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of histone deacetylase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome	IDA Inferred from Direct Assay more info	PubMed
part_of transcription repressor complex	IGI Inferred from Genetic Interaction more info	PubMed
part_of transcription repressor complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: ebi

Names: CG4063-PA; beta transducin-like 1 protein; ebi-PA; enhancer on chromosome 2-complementation group 2g

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

415067..418536

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057981.4 → NP_477329.1 ebi [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477329.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q95RJ9, Q9XZK1

UniProtKB/TrEMBL

C6SUT3, H1UUI8

Related

FBpp0077715

Conserved Domains (4) summary

cd00200
Location:349 → 655

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam08513
Location:6 → 32

LisH; LisH

pfam08662
Location:457 → 665

eIF2A; Eukaryotic translation initiation factor eIF2A

sd00039
Location:358 → 402

7WD40; WD40 repeat [structural motif]