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ND-15 NADH dehydrogenase (ubiquinone) 15 kDa subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33179, updated on 9-Dec-2024

Summary

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Official Symbol
ND-15provided by FlyBase
Official Full Name
NADH dehydrogenase (ubiquinone) 15 kDa subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0031228
Locus tag
Dmel_CG11455
See related
AllianceGenome:FB:FBgn0031228
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11455; Dmel\CG11455; dNDUFS5; NDUFS5; NIPM
Summary
Predicted to be involved in mitochondrial respiratory chain complex I assembly. Part of respiratory chain complex I. Is expressed in several structures, including anlage in statu nascendi; embryonic/larval midgut primordium; endoderm anlage; larval muscle cell; and mesoderm. Orthologous to human NDUFS5 (NADH:ubiquinone oxidoreductase subunit S5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See ND-15 in Genome Data Viewer
Location:
21B2-21B3; 2-0.5 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (114726..156030)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (114726..156030)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Cysteine rich with EGF like domains Neighboring gene Na[+]/H[+] hydrogen exchanger 1 Neighboring gene S-adenosylmethionine Synthetase Neighboring gene antisense RNA:CR44969 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44185 Neighboring gene long non-coding RNA:CR44186 Neighboring gene Glutamine synthetase 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene oven mitt Neighboring gene uncharacterized protein Neighboring gene Pseudouridine synthase 10 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene split ends

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ret rescues mitochondrial morphology and muscle degeneration of Drosophila Pink1 mutants. Klein P, et al. EMBO J, 2014 Feb 18. PMID 24473149, Free PMC Article
  2. TRAP1 rescues PINK1 loss-of-function phenotypes. Zhang L, et al. Hum Mol Genet, 2013 Jul 15. PMID 23525905, Free PMC Article
  3. The yeast complex I equivalent NADH dehydrogenase rescues pink1 mutants. Vilain S, et al. PLoS Genet, 2012 Jan. PMID 22242018, Free PMC Article
  4. Mutations in Complex I of the Mitochondrial Electron-Transport Chain Sensitize the Fruit Fly (Drosophila melanogaster) to Ether and Non-Ether Volatile Anesthetics. Borchardt LA, et al. Int J Mol Sci, 2023 Jan 17. PMID 36768163, Free PMC Article
  5. Senescent glia link mitochondrial dysfunction and lipid accumulation. Byrns CN, et al. Nature, 2024 Jun. PMID 38839958, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 116518-116976 mobile_element_type = transposon:INE-1{}2496

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in mitochondrial electron transport, NADH to ubiquinone IC
Inferred by Curator
more info
 PubMed 
involved_in mitochondrial respiratory chain complex I assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IC
Inferred by Curator
more info
 PubMed 
part_of respiratory chain complex I IDA
Inferred from Direct Assay
more info
 PubMed 
part_of respiratory chain complex I ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
NADH dehydrogenase (ubiquinone) 15 kDa subunit
Names
CG11455-PA
CG11455-PB
CG11455-PC
CG11455-PD
CG11455-PF
CG11455-PG
CG11455-PH
CG11455-PI
CG11455-PJ
CG11455-PK
NADH ubiquinone oxidoreductase 15 kDa
NADH-ubiquinone oxidoreductase 15 kDa subunit
NADH:ubiquinone oxidoreductase 15 kDa subunit
ND-15-PA
ND-15-PB
ND-15-PC
ND-15-PD
ND-15-PF
ND-15-PG
ND-15-PH
ND-15-PI
ND-15-PJ
ND-15-PK

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    114726..156030
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272863.1 → NP_001259792.1  NADH dehydrogenase (ubiquinone) 15 kDa subunit, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259792.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K1C0
    Conserved Domains (1) summary
    pfam10200
    Location:21 → 79
    Ndufs5; NADH:ubiquinone oxidoreductase, NDUFS5-15kDa

  2. NM_001258886.1 → NP_001245815.1  NADH dehydrogenase (ubiquinone) 15 kDa subunit, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245815.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K1C0
    Conserved Domains (1) summary
    pfam10200
    Location:21 → 79
    Ndufs5; NADH:ubiquinone oxidoreductase, NDUFS5-15kDa

  3. NM_001272864.1 → NP_001259793.1  NADH dehydrogenase (ubiquinone) 15 kDa subunit, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259793.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PBY4
    Conserved Domains (1) summary
    pfam10200
    Location:4 → 48
    Ndufs5; NADH:ubiquinone oxidoreductase, NDUFS5-15kDa

  4. NM_001272866.1 → NP_001259795.1  NADH dehydrogenase (ubiquinone) 15 kDa subunit, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259795.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K1C0
    Conserved Domains (1) summary
    pfam10200
    Location:21 → 79
    Ndufs5; NADH:ubiquinone oxidoreductase, NDUFS5-15kDa

  5. NM_001272867.1 → NP_001259796.1  NADH dehydrogenase (ubiquinone) 15 kDa subunit, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259796.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K1C0
    Conserved Domains (1) summary
    pfam10200
    Location:21 → 79
    Ndufs5; NADH:ubiquinone oxidoreductase, NDUFS5-15kDa

  6. NM_164372.3 → NP_722613.1  NADH dehydrogenase (ubiquinone) 15 kDa subunit, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_722613.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K1C0
    Related
    FBpp0077777
    Conserved Domains (1) summary
    pfam10200
    Location:21 → 79
    Ndufs5; NADH:ubiquinone oxidoreductase, NDUFS5-15kDa

  7. NM_001169371.2 → NP_001162842.1  NADH dehydrogenase (ubiquinone) 15 kDa subunit, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162842.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K1C0
    Conserved Domains (1) summary
    pfam10200
    Location:21 → 79
    Ndufs5; NADH:ubiquinone oxidoreductase, NDUFS5-15kDa

  8. NM_164371.3 → NP_722612.1  NADH dehydrogenase (ubiquinone) 15 kDa subunit, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_722612.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K1C0
    Related
    FBpp0077776
    Conserved Domains (1) summary
    pfam10200
    Location:21 → 79
    Ndufs5; NADH:ubiquinone oxidoreductase, NDUFS5-15kDa

  9. NM_001272865.2 → NP_001259794.1  NADH dehydrogenase (ubiquinone) 15 kDa subunit, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259794.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PBY4
    Conserved Domains (1) summary
    pfam10200
    Location:4 → 48
    Ndufs5; NADH:ubiquinone oxidoreductase, NDUFS5-15kDa

  10. NM_001169370.2 → NP_001162841.1  NADH dehydrogenase (ubiquinone) 15 kDa subunit, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162841.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K1C0
    Conserved Domains (1) summary
    pfam10200
    Location:21 → 79
    Ndufs5; NADH:ubiquinone oxidoreductase, NDUFS5-15kDa
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PBY4 M9PBY4
Q7K1C0 Q7K1C0

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