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CG17598 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33140, updated on 9-Dec-2024

Summary

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Official Symbol
CG17598provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0031194
Locus tag
Dmel_CG17598
See related
AllianceGenome:FB:FBgn0031194
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG17598; PP2C
Summary
Predicted to enable [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity. Predicted to be involved in signal transduction. Predicted to be located in cytoplasm and nucleus. Predicted to be active in mitochondrion. Is expressed in organism. Orthologous to several human genes including PPM1J (protein phosphatase, Mg2+/Mn2+ dependent 1J). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG17598 in Genome Data Viewer
Location:
20C1-20C1; 1-66 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (22534831..22540383, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (21936667..21942219, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43493 Neighboring gene lethal (1) G0196 Neighboring gene long non-coding RNA:CR43962 Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein S6 kinase II Neighboring gene Clusterin associated protein 1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The S6KII (rsk) gene of Drosophila melanogaster differentially affects an operant and a classical learning task. Putz G, et al. J Neurosci, 2004 Nov 3. PMID 15525759, Free PMC Article
  2. A phosphoswitch at acinus-serine(437) controls autophagic responses to cadmium exposure and neurodegenerative stress. Nandi N, et al. Elife, 2022 Jan 17. PMID 35037620, Free PMC Article
  3. Functional screening in Drosophila reveals the conserved role of REEP1 in promoting stress resistance and preventing the formation of Tau aggregates. Appocher C, et al. Hum Mol Genet, 2014 Dec 20. PMID 25096240
  4. Genome-wide RNAi screening implicates the E3 ubiquitin ligase Sherpa in mediating innate immune signaling by Toll in Drosophila adults. Kanoh H, et al. Sci Signal, 2015 Oct 27. PMID 26508789
  5. Expression of cardiac myosin-binding protein-C (cMyBP-C) in Drosophila as a model for the study of human cardiomyopathies. Vu Manh TP, et al. Hum Mol Genet, 2005 Jan 1. PMID 15525659

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cation binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG17598-PA
CG17598-PB
NP_001259780.1
NP_608468.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    22534831..22540383 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272851.1 → NP_001259780.1  uncharacterized protein Dmel_CG17598, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259780.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T991, Q9VR62
    Conserved Domains (1) summary
    cd00143
    Location:98 → 506
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

  2. NM_134624.4 → NP_608468.1  uncharacterized protein Dmel_CG17598, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608468.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T991, Q9VR62
    Related
    FBpp0077056
    Conserved Domains (1) summary
    cd00143
    Location:98 → 506
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VR62 Q9VR62

Gene LinkOut

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