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wap wings apart [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33131, updated on 9-Dec-2024

Summary

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Official Symbol
wapprovided by FlyBase
Official Full Name
wings apartprovided by FlyBase
Primary source
FLYBASE:FBgn0266848
Locus tag
Dmel_CG14614
See related
AllianceGenome:FB:FBgn0266848
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
15; 16; 19; 20; 21; 22; BcDNA:GM08142; CG14614; Dmel\CG14614; l(1)20Ab; l(1)A-200; l(1)HM33; l(1)Q217; l(1)Q464; Q217; Q464; riq; Riq; WAP
Summary
Enables protein-macromolecule adaptor activity. Involved in several processes, including myoblast development; positive regulation of organ growth; and regulation of signal transduction. Is active in nucleus. Orthologous to human DCAF7 (DDB1 and CUL4 associated factor 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See wap in Genome Data Viewer
Location:
20C1-20C1; 1-66 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (22451445..22455422, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (21853281..21857258, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene touch insensitive larva B Neighboring gene Ubiquitin specific protease 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DCAF7 regulates cell proliferation through IRS1-FOXO1 signaling. Frendo-Cumbo S, et al. iScience, 2022 Oct 21. PMID 36248734, Free PMC Article
  2. Hearing in Drosophila requires TilB, a conserved protein associated with ciliary motility. Kavlie RG, et al. Genetics, 2010 May. PMID 20215474, Free PMC Article
  3. Minibrain and Wings apart control organ growth and tissue patterning through down-regulation of Capicua. Yang L, et al. Proc Natl Acad Sci U S A, 2016 Sep 20. PMID 27601662, Free PMC Article
  4. DYRK1A and cognition: A lifelong relationship. Arbones ML, et al. Pharmacol Ther, 2019 Feb. PMID 30268771
  5. Characterization of the flamenco region of the Drosophila melanogaster genome. Robert V, et al. Genetics, 2001 Jun. PMID 11404334, Free PMC Article

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein-macromolecule adaptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in muscle cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in muscle organ development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in myoblast development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of hippo signaling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of hippo signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of organ growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
wings apart
Names
CG14614-PA
CG14614-PB
CG14614-PC
CG14614-PD
riquiqui
section 15
section 16
section 19
section 20
section 21
section 22
wap-PA
wap-PB
wap-PC
wap-PD
wings-apart

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    22451445..22455422 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298597.1 → NP_001285526.1  wings apart, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285526.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VR53
    Conserved Domains (2) summary
    sd00039
    Location:75 → 117
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:19 → 295
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_001258869.3 → NP_001245798.1  wings apart, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245798.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VR53
    Conserved Domains (2) summary
    sd00039
    Location:75 → 117
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:19 → 295
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. NM_134617.5 → NP_608461.1  wings apart, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608461.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VR53
    Related
    FBpp0077060
    Conserved Domains (2) summary
    sd00039
    Location:75 → 117
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:19 → 295
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. NM_001258868.3 → NP_001245797.1  wings apart, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245797.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VR53
    Conserved Domains (2) summary
    sd00039
    Location:75 → 117
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:19 → 295
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95S63 Q95S63
Q95T24 Q95T24
Q9VR53 Q9VR53

Gene LinkOut

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