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mst misato [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33119, updated on 4-Jan-2025

Summary

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Official Symbol
mstprovided by FlyBase
Official Full Name
misatoprovided by FlyBase
Primary source
FLYBASE:FBgn0020272
Locus tag
Dmel_CG1424
See related
AllianceGenome:FB:FBgn0020272
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1424; Dmel\CG1424; l(1)19Fg; l(1)LB14; l(1)LB20; LB-20; LB20; lLB14; MST1/2
Summary
Involved in mitotic spindle assembly. Located in cytoplasm. Is expressed in adult brain; brain; embryonic/larval fat body; imaginal disc; and ovary. Used to study myotonia congenita. Orthologous to human MSTO1 (misato mitochondrial distribution and morphology regulator 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See mst in Genome Data Viewer
Location:
20A1-20A1; 1-66 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (21388977..21391533)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (21260004..21262560)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45611 Neighboring gene sluggish A Neighboring gene ncRNA Neighboring gene DEAD-box helicase 56 Neighboring gene long non-coding RNA:CR45500 Neighboring gene la costa

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Preliminary characterisation of DML1, an essential Saccharomyces cerevisiae gene related to misato of Drosophila melanogaster. Gurvitz A, et al. FEMS Yeast Res, 2002 May. PMID 12702300
  2. An essential cell division gene of Drosophila, absent from Saccharomyces, encodes an unusual protein with tubulin-like and myosin-like peptide motifs. Miklos GL, et al. Proc Natl Acad Sci U S A, 1997 May 13. PMID 9144213, Free PMC Article
  3. Genomic imprinting in Drosophila has properties of both mammalian and insect imprinting. Anaka M, et al. Dev Genes Evol, 2009 Feb. PMID 19031081
  4. Age-dependent expression profiles of two adaptogenic systems and thermotolerance in Drosophila melanogaster. Shilova V, et al. Cell Stress Chaperones, 2020 Mar. PMID 32040825, Free PMC Article
  5. Phenotypic analysis of misato function reveals roles of noncentrosomal microtubules in Drosophila spindle formation. Mottier-Pavie V, et al. J Cell Sci, 2011 Mar 1. PMID 21285248

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Misato Controls Mitotic Microtubule Generation by Stabilizing the TCP-1 Tubulin Chaperone Complex.
    Title: Misato Controls Mitotic Microtubule Generation by Stabilizing the TCP-1 Tubulin Chaperone Complex [corrected].
  2. sData how that mutations in the Drosophila misato gene inhibit kinetochore-driven microtubule growth, lead to the formation of monopolar spindles and cause larval lethality.
    Title: Phenotypic analysis of misato function reveals roles of noncentrosomal microtubules in Drosophila spindle formation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrion organization IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic sister chromatid segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
misato
Names
CG1424-PA
CG1424-PB
MST1/2
lethal(1)19Fg
mst-PA
mst-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    21388977..21391533
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298589.1 → NP_001285518.1  misato, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285518.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O01939, Q8MSB2
    UniProtKB/TrEMBL
    X2JG23
    Conserved Domains (1) summary
    cd06060
    Location:5 → 570
    misato; Misato segment II tubulin-like domain

  2. NM_078711.5 → NP_523435.1  misato, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523435.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O01939, Q8MSB2
    UniProtKB/TrEMBL
    X2JG23
    Related
    FBpp0076907
    Conserved Domains (1) summary
    cd06060
    Location:5 → 570
    misato; Misato segment II tubulin-like domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O01939.1 O01939
X2JG23 X2JG23

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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