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Abca3 ATP binding cassette subfamily A member 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33103, updated on 4-Jan-2025

Summary

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Official Symbol
Abca3provided by FlyBase
Official Full Name
ATP binding cassette subfamily A member 3provided by FlyBase
Primary source
FLYBASE:FBgn0031170
Locus tag
Dmel_CG1718
See related
AllianceGenome:FB:FBgn0031170
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ABCA; CG1718; dABCA; DmCG1718; Dmel\CG1718
Summary
Predicted to enable ATPase-coupled transmembrane transporter activity and lipid transporter activity. Predicted to be involved in lipid transport. Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in adult head and organism. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in pulmonary alveolar proteinosis. Orthologous to human ABCA3 (ATP binding cassette subfamily A member 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Abca3 in Genome Data Viewer
Location:
19F3-19F3; 1-65 cM
Exon count:
15
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (21292308..21306665, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (21163335..21177692, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Membrane-bound Notch regulator Neighboring gene transfer RNA:Arginine-TCG 2-2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Tyrosine-GTA 1-1 Neighboring gene transfer RNA:Tyrosine-GTA 2-1 Neighboring gene mir-1007 stem loop Neighboring gene mir-2535b stem loop Neighboring gene uncharacterized protein Neighboring gene SRA stem-loop interacting RNA binding protein 1 Neighboring gene Regulatory particle triple-A ATPase 6 Neighboring gene anorexia

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Novel Drosophila model for psychiatric disorders including autism spectrum disorder by targeting of ATP-binding cassette protein A. Ueoka I, et al. Exp Neurol, 2018 Feb. PMID 29092799
  2. The ABC Transporter Eato Promotes Cell Clearance in the Drosophila melanogaster Ovary. Santoso CS, et al. G3 (Bethesda), 2018 Mar 2. PMID 29295819, Free PMC Article
  3. Novel genetic link between the ATP-binding cassette subfamily A gene and hippo gene in Drosophila. Ueoka I, et al. Exp Cell Res, 2020 Jan 15. PMID 31751555
  4. Induction of Apoptosis and Subsequent Phagocytosis of Virus-Infected Cells As an Antiviral Mechanism. Nainu F, et al. Front Immunol, 2017. PMID 29033939, Free PMC Article
  5. Neuronal ROS-induced glial lipid droplet formation is altered by loss of Alzheimer's disease-associated genes. Moulton MJ, et al. Proc Natl Acad Sci U S A, 2021 Dec 28. PMID 34949639, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Novel genetic link between the ATP-binding cassette subfamily A gene and hippo gene in Drosophila has been documented.
    Title: Novel genetic link between the ATP-binding cassette subfamily A gene and hippo gene in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATPase-coupled transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in lipid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
ATP binding cassette subfamily A member 3
Names
ATP binding cassette subfamily A
Abca3-PB
Abca3-PC
Abca3-PD
CG1718-PB
CG1718-PC
CG1718-PD
NP_001259764.1
NP_001259765.1
NP_608445.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    21292308..21306665 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_134601.3 → NP_608445.2  ATP binding cassette subfamily A member 3, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608445.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VRG4
    Conserved Domains (5) summary
    TIGR01188
    Location:1376 → 1702
    drrA; daunorubicin resistance ABC transporter ATP-binding subunit
    cd03263
    Location:538 → 755
    ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A
    COG1131
    Location:538 → 843
    CcmA; ABC-type multidrug transport system, ATPase component [Defense mechanisms]
    pfam12698
    Location:913 → 1316
    ABC2_membrane_3; ABC-2 family transporter protein
    pfam12730
    Location:254 → 434
    ABC2_membrane_4; ABC-2 family transporter protein

  2. NM_001272836.1 → NP_001259765.1  ATP binding cassette subfamily A member 3, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259765.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PHQ1
    Conserved Domains (5) summary
    TIGR01188
    Location:1354 → 1680
    drrA; daunorubicin resistance ABC transporter ATP-binding subunit
    cd03263
    Location:516 → 733
    ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A
    COG1131
    Location:516 → 821
    CcmA; ABC-type multidrug transport system, ATPase component [Defense mechanisms]
    pfam12698
    Location:891 → 1294
    ABC2_membrane_3; ABC-2 family transporter protein
    pfam12730
    Location:232 → 412
    ABC2_membrane_4; ABC-2 family transporter protein

  3. NM_001272835.1 → NP_001259764.1  ATP binding cassette subfamily A member 3, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259764.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PFD0
    Conserved Domains (5) summary
    TIGR01188
    Location:1354 → 1680
    drrA; daunorubicin resistance ABC transporter ATP-binding subunit
    cd03263
    Location:516 → 733
    ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A
    COG1131
    Location:516 → 821
    CcmA; ABC-type multidrug transport system, ATPase component [Defense mechanisms]
    pfam12698
    Location:891 → 1294
    ABC2_membrane_3; ABC-2 family transporter protein
    pfam12730
    Location:232 → 412
    ABC2_membrane_4; ABC-2 family transporter protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PFD0 M9PFD0
M9PHQ1 M9PHQ1
Q9VRG4 Q9VRG4

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