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bves bves [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33083, updated on 4-Jan-2025

Summary

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Official Symbol
bvesprovided by FlyBase
Official Full Name
bvesprovided by FlyBase
Primary source
FLYBASE:FBgn0031150
Locus tag
Dmel_CG32513
See related
AllianceGenome:FB:FBgn0031150
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:SD21670; CG1544; CG15448; CG1754; CG32513; Dmel\CG32513
Summary
Predicted to enable cAMP binding activity. Predicted to be involved in several processes, including cell-cell adhesion; heart development; and striated muscle cell differentiation. Predicted to be located in membrane. Predicted to be active in sarcolemma. Is expressed in adult head; follicle cell; and nurse cell. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy and autosomal recessive limb-girdle muscular dystrophy type 2X. Orthologous to several human genes including POPDC1 (popeye domain cAMP effector 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See bves in Genome Data Viewer
Location:
19E7-19E8; 1-65 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (21053963..21082391)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (20924990..20953418)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene small Cajal body-specific RNA : MeU2-C28 Neighboring gene Catalytic subunit 3A of the oligosaccharyltransferase complex Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene stargazin-like protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Blood vessel/epicardial substance (bves) expression, essential for embryonic development, is down regulated by Grk/EFGR signalling. Lin S, et al. Int J Dev Biol, 2007. PMID 17183463
  2. Partial loss of GATA factor Pannier impairs adult heart function in Drosophila. Qian L, et al. Hum Mol Genet, 2009 Sep 1. PMID 19494035, Free PMC Article
  3. Sex-Specific Transcript Diversity in the Fly Head Is Established during Pupal Stages and Adulthood and Is Largely Independent of the Mating Process and the Germline. Mohr C, et al. Sex Dev, 2017. PMID 28273663
  4. Ethanol-regulated genes that contribute to ethanol sensitivity and rapid tolerance in Drosophila. Kong EC, et al. Alcohol Clin Exp Res, 2010 Feb. PMID 19951294, Free PMC Article
  5. Drosophila models to study causative genes for human rare intractable neurological diseases. Yamaguchi M, et al. Exp Cell Res, 2021 Jun 1. PMID 33812867

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study shows that the repression of bves expression in anterior-dorsal follicle cells is regulated by the Grk/EGFR signalling pathway.
    Title: Blood vessel/epicardial substance (bves) expression, essential for embryonic development, is down regulated by Grk/EFGR signalling.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cAMP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell-cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in heart development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in striated muscle cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in sarcolemma IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
bves
Names
CG32513-PA
CG32513-PB
CG32513-PC
CG32513-PD
bves-PA
bves-PB
bves-PC
bves-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    21053963..21082391
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_134582.4 → NP_608426.1  bves, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608426.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9GTX4, Q9VRE2
    Related
    FBpp0076939
    Conserved Domains (1) summary
    pfam04831
    Location:98 → 320
    Popeye; Popeye protein conserved region

  2. NM_001272823.1 → NP_001259752.1  bves, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259752.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G7H830
    Conserved Domains (1) summary
    pfam04831
    Location:98 → 320
    Popeye; Popeye protein conserved region

  3. NM_001272824.1 → NP_001259753.1  bves, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259753.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PJS1
    Conserved Domains (1) summary
    pfam04831
    Location:98 → 320
    Popeye; Popeye protein conserved region

  4. NM_206800.3 → NP_996523.1  bves, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996523.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9GTX4, Q9VRE2
    Conserved Domains (1) summary
    pfam04831
    Location:98 → 320
    Popeye; Popeye protein conserved region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G7H830 G7H830
M9PJS1 M9PJS1
Q8MRV2 Q8MRV2
Q9VRE2 Q9VRE2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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