B4galnt4 beta-1,4-N-acetyl-galactosaminyl transferase 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: B4galnt4provided by MGI
Official Full Name: beta-1,4-N-acetyl-galactosaminyl transferase 4provided by MGI
Primary source: MGI:MGI:2652891
See related: Ensembl:ENSMUSG00000055629 AllianceGenome:MGI:2652891
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm1095; NGalNAc-T1; beta4GalNAcT4
Summary: Predicted to enable acetylgalactosaminyltransferase activity. Predicted to be involved in chondroitin sulfate biosynthetic process. Predicted to be located in Golgi cisterna membrane. Is expressed in bronchiole; lung epithelium; metanephros; ureteric tip; and ureteric trunk. Orthologous to human B4GALNT4 (beta-1,4-N-acetyl-galactosaminyltransferase 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in CNS E18 (RPKM 44.9), whole brain E14.5 (RPKM 39.5) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F5; 7 86.32 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (140640891..140652313)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (141060978..141072400)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Peptide-specific transfer of N-acetylgalactosamine to O-linked glycans by the glycosyltransferases beta1,4-N-acetylgalactosaminyl transferase 3 (beta4GalNAc-T3) and beta4GalNAc-T4.
Title: Peptide-specific transfer of N-acetylgalactosamine to O-linked glycans by the glycosyltransferases β1,4-N-acetylgalactosaminyl transferase 3 (β4GalNAc-T3) and β4GalNAc-T4.
Molecular basis for protein-specific transfer of N-acetylgalactosamine to N-linked glycans by the glycosyltransferases beta1,4-N-acetylgalactosaminyl transferase 3 (beta4GalNAc-T3) and beta4GalNAc-T4.
Title: Molecular basis for protein-specific transfer of N-acetylgalactosamine to N-linked glycans by the glycosyltransferases β1,4-N-acetylgalactosaminyl transferase 3 (β4GalNAc-T3) and β4GalNAc-T4.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

General gene information

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Markers

RH125113 (e-PCR)
- UniSTS:161935

D10Bwg0134e (e-PCR), detects polymorphism
- UniSTS:141488

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acetylgalactosaminyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetylgalactosaminyltransferase activity	ISO Inferred from Sequence Orthology more info
enables acetylgalactosaminyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chondroitin sulfate biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi cisterna membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1

Names: beta 1,4-N-acetylgalactosaminyltransferase-transferase 4; beta-1,4-N-acetylgalactosaminyltransferase IV; beta1,4-N-acetylgalactosaminyltransferase IV; beta4GalNAc-T4

NP_808565.2

EC 2.4.1.244

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177897.4 → NP_808565.2 N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1

See identical proteins and their annotated locations for NP_808565.2

Status: VALIDATED

Source sequence(s)

AC109272

Consensus CDS

CCDS21998.1

UniProtKB/Swiss-Prot

Q766D5, Q8CHV2

Related

ENSMUSP00000039758.6, ENSMUST00000048002.7

Conserved Domains (2) summary

cl08459
Location:143 → 277

PA14; PA14 domain

cl11394
Location:706 → 1015

Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold